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    SR-717 lithium
    SR-717 lithium

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V2205
    CAS #: 2375421-09-1Purity ≥98%

    Description: SR-717 lithium is a novel, potent and  non-nucleotide STING (stimulator of interferon genes) agonist with anticancer activities. It has EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same 'closed' conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.

    References: Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. 2020 Aug 21;369(6506):993-999.

    Related CAS #: 2375420-34-9 (free acid) 2375421-09-1 (lithium)  

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    Molecular Formula: C15H8F2LiN5O3
    Molecular Weight: 351.1978
    Elemental Analysis: C, 51.30; H, 2.30; F, 10.82; Li, 1.98; N, 19.94; O, 13.67

    Related CAS #: 2375420-34-9 (free)   2375421-09-1 (lithium)    

    Synonym: SR-717 lithium; SR 717 lithium; SR717 lithium;

    Chemical Name: lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate

    InChi Key: ODSAJRWPLSVEHJ-UHFFFAOYSA-M

    InChi Code: InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1

    SMILES Code: O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+]


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