Size | Price | Stock | Qty |
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1mg |
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Other Sizes |
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ln Vivo |
Mice with bilateral B16-OVA melanomas have enhanced anticancer activity when administered intratumorally with IACS-8803 (10 µg)[1].
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References |
[1]. Ager CR, et al. Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640.
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Molecular Formula |
C20H23FN10NA2O9P2S2
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Molecular Weight |
738.51
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CAS # |
2243079-36-7
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Related CAS # |
IACS-8803 diammonium;IACS-8803;2095690-70-1
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SMILES |
OC1([H])[C@@]2([H])CO[P@](O[C@@]3([H])[C@@H](F)[C@H](N4C=NC5=C(N=CN=C45)N)O[C@]3([H])CO[P@](S)(=O)O[C@@]1([H])[C@H](N1C=NC3=C(N=CN=C13)N)O2)(S)=O.[NaH]
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O: 56.67 mg/mL (76.74 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (67.70 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.3541 mL | 6.7704 mL | 13.5408 mL | |
5 mM | 0.2708 mL | 1.3541 mL | 2.7082 mL | |
10 mM | 0.1354 mL | 0.6770 mL | 1.3541 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.