A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75155 | Apterin | 53947-89-0 | Apterin is a natural compound with anti-inflammatory activity. |
|
V75154 | AR-C102222 | 253771-21-0 | AR-C102222 is a spirocyclic haloperidine-quinazoline selective iNOS inhibitor. |
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V51464 | ARL-17477 HCl | 866914-87-6 | ARL-17477 is a dual activator of NOS1 and the autophagosome system with anti-cancer activity that suppresses the growth of KRAS-mutated tumors. |
|
V75106 | Asymmetric dimethylarginine dihydrochloride (NG,NG-Dimethylarginine dihydrochloride) | 220805-22-1 | Asymmetric dimethylarginine di-HCl is an endogenous NO synthase (NO synthase) inhibitor that can reduce the production of NO, leading to endothelial dysfunction and cardiovascular disease. |
|
V22321 | Biopterin | 22150-76-1 | 6-Biopterin (L-Biopterin), a pterin analogue, is a cofactor of nitric oxide synthase (NO synthase). |
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V75109 | Bisacurone | 120681-81-4 | Bisacurone is a natural terpenoid with inhibitory activity against LPS-induced NO production with IC50 of 29.8 μM. |
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V75139 | Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Di-O-acetylbritannilactone) | 1286694-67-4 | Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) has potential NO inhibitory effects. |
|
V75102 | Camstatin | 1002295-95-5 | Camstatin is an active 25-residue fragment of the PEP-19 IQ motif that binds calmodulin and inhibits neuronal nitric oxide synthase (NO synthase). |
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V78618 | Camstatin TFA | Camstatin TFA is an active 25-residue fragment of the PEP-19 IQ motif that binds calmodulin and inhibits neuronal nitric oxide synthase (NO synthase). | |
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V75138 | Canophyllal | 14440-40-5 | Canophyllal is a triterpene compound extracted from the leaves of Elsholtzia ciliata. |
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V75099 | Carboxy-PTIO | 145757-47-7 | Carboxy-PTIO is an effective nitric oxide (NO) scavenger that reacts quickly with NO to produce NO2. |
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V71262 | Celiprolol-d9 hydrochloride (REV 5320-d9 hydrochloride) | 1215535-20-8 | Celiprolol-d9 (HCl) is the deuterium labelled form of Celiprolol HCl. |
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V75143 | Chloranthalactone E | 73215-92-6 | Chloranthalactone E (compound 6) is a labane diterpene that can be extracted from the aerial parts of Chloranthus serratus. |
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V75105 | Citroside A | 120330-44-1 | Citroside A is a sesquiterpenoid from C.giganteum that displays cytotoxic and anti-inflammatory activities. |
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V75114 | D-NAME hydrochloride (D-NG-nitroarginine methyl ester hydrochloride; HD-Arg(NO2)-OMe hydrochloride) | 50912-92-0 | D-NAME HCl (D-NG-nitroarginine methyl ester) is a potent nitric oxide synthase (NOS) inhibitor. |
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V73511 | Damnacanthol | 477-83-8 | Damnacanthol is a naturally occurring compound extracted from Damnacanthus major. |
|
V75093 | DETA NONOate (Diethylamine NONOate; NOC-18) | 146724-94-9 | DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. |
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V75124 | Dimeric coniferyl acetate | 184046-40-0 | Dimeric coniferylacetate is an inhibitor (blocker/antagonist) of NO production with IC50 of 7.9 μM in BV-2 microglia. |
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V14325 | Dimethoxycurcumin | 160096-59-3 | Dimethoxycurcumin is a synthetic and metabolically more stable urcumin analogue with anti-inflammatory and antioxidant activities, inducing epigenetic changes in leukemia cells and the expression of promoter methylated genes. |
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V75108 | GW274150 dihydrochloride | 438542-17-7 | GW274150 (di-HCl) is a specific, orally bioactive NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (Kd=40 nM) and rat (iNOS). |
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