A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75103 | Myricananin A | 1079941-35-7 | Myricananin A is a colorless needle-like substance that can inhibit iNOS. |
|
V75153 | N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide; cis-N-Feruloyltyramine) | 80510-09-4 | N-cis-Feruloyl tyramine (cis-N-(4-Hydroxypheneth) ferulamide) is a natural phenolic compound with moderate inhibitory activity on LPS-activated NO production in RAW 264.7 cells. |
|
V75129 | Nitric oxide production-IN-1 | 1013405-26-9 | Nitric oxide production-IN-1 (Compound 1) is an inhibitor (blocker/antagonist) of NO Production extracted from Tupistra chinensis. |
|
V75118 | NOS-IN-1 | 165383-72-2 | NOS-IN-1 is a potent orally bioactive nitric oxide synthase (NOS) inhibitor (antagonist) with IC50s of 0.1 μM, 1.1 μM and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS respectively. |
|
V75115 | NOS-IN-2 | 2766146-79-4 | NOS-IN-2 (Compound 4i) is a potent and specific imidamide-derived NOS inhibitor (antagonist) with IC50 of 20 µM for iNOS. |
|
V75098 | NOS1-IN-1 | 357965-99-2 | NOS1-IN-1 is a selective, cell-permeable (penetrable) nNOS inhibitor (antagonist) with a Ki of 120 nM. |
|
V5303 | NQN-1 (PPM-18) | 65240-86-0 | NQN-1 (PPM-18), a chemically synthesized naphthoquinone derivative and an anti-inflammatory agent, is a novel, potent and cell-permeable and anti-inflammatory agent shown to express inhibitory effects of iNOS through the blocking of NF kappa B activationin vitro. |
|
V75101 | Nω-allyl-L-arginine | 139461-37-3 | Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS). |
|
V75100 | Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) | 137361-05-8 | Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a highly efficient, competitive, and selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 57 nM. |
|
V75126 | O-Acetylschisantherin L (Acetylschisantherin L) | 149998-51-6 | O-Acetylschisantherin L (Acetylschisantherin L) is a natural lignan that can inhibit LPS-induced NO production in BV-2 cells with IC50 of 23.1 μM. |
|
V75128 | Oxyphyllenone A ((+)-Oxyphyllenone A) | 363610-34-8 | Oxyphyllenone A is an inhibitor (blocker/antagonist) of NO Synthase. |
|
V75130 | paneolilludinic acid | 847586-20-3 | Paneolilludinic acid is a compound extracted from the endophytic fungus Cryptomarasmius aucubae. |
|
V75120 | Physalin O | 120849-18-5 | Physalin O is a picrin that can be extracted from bittern. |
|
V75142 | Randaiol (Magnotriol A) | 87562-14-9 | Randaiol is an anti-inflammatory agent extracted from the stem bark of Magnolia officinalis. |
|
V75156 | Rubranol | 211126-61-3 | Rubranol is an inhibitor (blocker/antagonist) of NO Synthase. |
|
V75133 | S-MTC dihydrochloride (S-Methyl-L-thiocitrulline dihydrochloride) | 209589-59-3 | S-MTC (S-Methyl-L-thiocitrulline) diHCl is a selective inhibitor of type I nitric oxide synthase (NOS). |
|
V75147 | Schiarisanrin A (Kadsulignan J) | 130252-41-4 | Schiarisanrin A (Kadsulignan J) is a lignan with inhibitory activity on NO production. |
|
V79652 | Septeremophilane E | Septeremophilane E is a compound extracted from the fungus Septoria rudbeckiae, a phytopathogenic fungus extracted from the halophyte Karelinia caspia. | |
|
V51048 | Shizukaol B | 142279-40-1 | Shizukaol B is a linden-type dimeric sesquiterpenoid that was extracted from the whole plant of Chloranthus henryi. |
|
V75137 | Valeriandoid F | 1427162-60-4 | Valeriandoid F is an iridoid that can effectively inhibit NO production with IC50 of 0.88 μM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
