A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75150 | Vinyl-L-NIO hydrochloride | 728944-69-2 | Vinyl-L-NIO HCl is a potent nitric oxide synthase (NOS) inhibitor. |
|
V71587 | Zevaquenabant ((S)-MRI-1867) | 1998760-00-1 | Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable cannabinoid CB1 receptor and inducible NOS (iNOS) dual antagonist. |
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