The host's innate immune system and immune homeostasis depend heavily on the cytoplasmic pattern-recognition receptors (PRRs) known as nucleotide oligomerization domain (NOD)-like receptors (NLRs). Humans have 23 members of the NLR family, while mice have at least 34 NLR genes. Although many cell types, including immune and epithelial cells, express NLRs, some NLR family members, such as macrophages and neutrophils, express them primarily in phagocytes. The NLR family is most frequently divided into one of four subfamilies based on their N-terminal domains: NLRA, NLRB, NLRC, and NLRP.
The NLRs are capable of recognizing a wide range of ligands, including those produced by microbial pathogens (peptidoglycan, flagellin, viral RNA, fungal hyphae, etc.), host cells (ATPs, cholesterol crystals, uric acid, etc.), and environmental sources (alum, asbestos, silica, alloy particles, UV radiation, skin irritants, etc.). Most NLRs function as PRRs, identifying the aforementioned ligands and inciting inflammatory reactions. Some NLRs, however, might not function as PRRs and instead react to cytokines like interferons. Four broad categories of functions performed by the activated NLRs include inflammasome formation, signal transduction, transcription activation, and autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75162 | NLRP3-IN-13 | 1704638-35-6 | NLRP3-IN-13 (referred to as compound C77 in the patent) is a potent and specific NLRP3 inhibitor (IC50= 2.1 μM). |
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V75187 | NLRP3-IN-14 | 2767369-80-0 | NLRP3-IN-14 is a potent and specific inhibitor of the NLRP3 inflammasome (KD: 5.87 μM). |
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V75178 | NLRP3-IN-15 | 2767369-71-9 | NLRP3-IN-15 is a potent and specific inhibitor of the NLRP3 inflammasome (KD: 5.87 μM). |
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V75182 | NLRP3-IN-16 | 2906872-59-9 | NLRP3-IN-16 is a potent and specific inhibitor of the NLRP3 inflammasome. |
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V75188 | NLRP3-IN-17 | 2254432-75-0 | NLRP3-IN-17 is a specific, orally bioactive NLRP3 inflammasome inhibitor (antagonist) with IC50 of 7 nM. |
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V75165 | NLRP3-IN-18 | 2769040-06-2 | NLRP3-IN-18 (compound 13) is a potent NLRP3 inhibitor (antagonist) with IC50 of ≤ 1.0 µM[1]. |
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V75177 | NLRP3-IN-19 (NLRP3-IN-19) | 2238819-65-1 | NLRP3-IN-19 (JT001) is a potent, specific and orally bioactive NLRP3 inhibitor. |
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V75175 | NLRP3-IN-20 | 2428478-22-0 | NLRP3-IN-20 (compound 11) is an orally bioavailable inhibitor of the NLRP3 inflammasome, with IC50 of 25 nM for inhibiting IL-1β secretion. |
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V75179 | NLRP3-IN-21 | 2956791-61-8 | NLRP3-IN-21 (compound L38) is an NLRP3 inflammasome inhibitor (antagonist) with inflammatory properties. |
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V75184 | NLRP3-IN-22 | 1193329-98-4 | NLRP3-IN-22 (Compound II-4) is an NLRP3 inhibitor (inhibition rate: 67% at 10 μM). |
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V79047 | NLRP3-IN-23 | NLRP3-IN-23 (Compound 15C) is a heme-mediated inhibitor of NLRP3 inflammasome induction. | |
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V75176 | NLRP3-IN-4 | 2758595-77-4 | NLRP3-IN-4 is a potent orally bioactive NLRP3 inflammasome inhibitor (antagonist) with anti~inflammatory activity in colitis. |
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V75185 | NLRP3-IN-8 | 2768650-56-0 | NLRP3-IN-8 (compound 27) is an orally bioactive NLRP3 inflammasome inhibitor that directly binds to NLRP3, with IC50 of 1.23 μM for IL-1β. |
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V75169 | NLRP3-IN-9 | 2768759-64-2 | NLRP3-IN-9 is a potent NLRP3 inhibitor. |
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V75167 | NLRP3-IN-NBC6 | 2068818-02-8 | NLRP3-IN-NBC6 is a potent and specific inhibitor of the NLRP3 inflammasome (IC50= 574 nM), and its effect is Ca2+ independent. |
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V80952 | NLRP3/AIM2-IN-1 | NLRP3/AIM2-IN-1 is a thermal sepsis inhibitor that displays moderate anti-thermophotoactivity, with IC50 of 3.136±0.7667μM. | |
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V51066 | NLRP3/AIM2-IN-2 | 791840-86-3 | NLRP3/AIM2-IN-2 is a new and potent analogue targeting NLRP3 and AIM2 key body-dependent pyroptosis with different species topology. |
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V51065 | NLRP3/AIM2-IN-3 | 1787787-60-3 | NLRP3/AIM2-IN-3 (compound 59) is a potent reducing agent with different species-specific apoptotic effects on NLRP3 and AIM2 inflammasome-dependent pyroptosis. |
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V75183 | NP3-146 (NLRP3-IN-5) | 210826-47-4 | NLRP3-IN-5 is an NLRP3 inflammasome inhibitor (WO2016131098 (N-((4-chloro-2,6-dimethylphenyl)carbamoyl)-4-(2-hydroxypropan-2-l)furan-2-sulfonamide )). |
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V75173 | NT-0796 | 2272917-13-0 | NT-0796 is a selective, CNS-permeable (penetrable) NLRP3 inflammasome inhibitor (antagonist) with IC50 of 0.32 nM in the PBMC assay. |
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