The host's innate immune system and immune homeostasis depend heavily on the cytoplasmic pattern-recognition receptors (PRRs) known as nucleotide oligomerization domain (NOD)-like receptors (NLRs). Humans have 23 members of the NLR family, while mice have at least 34 NLR genes. Although many cell types, including immune and epithelial cells, express NLRs, some NLR family members, such as macrophages and neutrophils, express them primarily in phagocytes. The NLR family is most frequently divided into one of four subfamilies based on their N-terminal domains: NLRA, NLRB, NLRC, and NLRP.
The NLRs are capable of recognizing a wide range of ligands, including those produced by microbial pathogens (peptidoglycan, flagellin, viral RNA, fungal hyphae, etc.), host cells (ATPs, cholesterol crystals, uric acid, etc.), and environmental sources (alum, asbestos, silica, alloy particles, UV radiation, skin irritants, etc.). Most NLRs function as PRRs, identifying the aforementioned ligands and inciting inflammatory reactions. Some NLRs, however, might not function as PRRs and instead react to cytokines like interferons. Four broad categories of functions performed by the activated NLRs include inflammasome formation, signal transduction, transcription activation, and autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73557 | Oxidized ATP trisodium salt (oATP trisodium salt) | 71997-40-5 | Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor blocker/inhibitor. |
|
V75158 | QS-21 (Stimulon) | 141256-04-4 | QS-21 is an immunostimulatory saponin that serves as an effective vaccine adjuvant. |
|
V81385 | Selnoflast potassium (RO-7486967 potassium) | Selnoflast (potassium) (example 6) is an inhibitor (blocker/antagonist) of NLRP3 (information from patent WO2019008025). | |
|
V75160 | Selnolast (RO-7486967) | 2260969-36-4 | Selnoflast (example 6) is an inhibitor (blocker/antagonist) of NLRP3 (information from patent WO2019008025). |
|
V75170 | Selnolast calcium (RO-7486967 calcium) | 2887416-19-3 | Selnoflast calcium (example 6) is an inhibitor (blocker/antagonist) of NLRP3 (information from patent WO2019008025). |
|
V75171 | TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid) | 877462-71-0 | TriDAP (L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a biologically active peptide. |
|
V75159 | Usnolast | 2455519-86-3 | Usnoflast is an NLRP3 modulator and a nonsteroidal anti~inflammatory drug (NSAD). |
|
V2484 | YQ128 | 2454246-18-3 | YQ128 (YQ-128) is a novel, potent, selective and second-generation inhibitor of NOD-like receptor P3 (NLRP3) inflammasome (IC50= 0.30 µM) with anti-inflammatory activity. |
|
V75168 | β-Aminoarteether (SM934 free base) | 133162-24-0 | β-Aminoarteether (SM934 free base) is an orally bioactive Artemisinin analogue. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
