A family of proteins known as Bcl-2 have evolutionary connections. These proteins, which include Bcl-2 proper, Bcl-xL, and Bcl-w among a variety of others, control mitochondrial outer membrane permeabilization (MOMP). They can either be pro- or anti-apoptotic. The Bcl-2 family comprises a total of 25 known genes. These human genes include Bak1, Bax, Bal-2, Bok, and Mcl-1, which code for members of this family of proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V76049 | Bim-IN-1 | 2909483-36-7 | Bim-IN-1 is a potent inhibitor of Bim expression. |
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V78988 | BPA-B9 | BPA-B9 is a RXRα ligand and antagonist that targets the pRXRα-PLK1 interaction. | |
|
V17161 | BT2 | 34576-94-8 | BT2 is a BCKDC kinase (BDK) inhibitor (antagonist) with IC50 of 3.19 μM. |
|
V3168 | BTSA1 | 314761-14-3 | BTSA1 (BTSA-1) is a novel and potent BAX (BCL2-associated X protein) activator with antitumor activity. |
|
V4119 | CID5721353 | 301356-95-6 | CID5721353 (also known as BCL6 Inhibitor and 79-6) is a novel and potent inhibitor ofBCL6 (B-Cell Lymphoma 6)with anIC50value of 212 μM (equivalent to aKiof 147 μM). |
|
V40053 | DT2216 | 2365172-42-3 | DT2216 (DT-2216; DT 2216) is a novel and potent degrader ofB-cell lymphoma extra large (BCL-XL) based on proteolysis-targeting chimera (PROTAC) technology. |
|
V10003 | Gossypol | 303-45-7 | Gossypol binds to Bcl-xL protein and Bcl-2 protein respectively, with Kis of 0.5-0.6 μM and 0.2-0.3 mM respectively. |
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V78509 | Gossypol-13C2 (BL 193-13C2) | Gossypol-13C2 (BL 193-13C2) is an active compound. | |
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V0007 | HA14-1 | 65673-63-4 | HA14-1 is a novel, potent and non-peptidic inhibitor of a B-cell lymphoma 2 (Bcl-2)surface pocket with IC50 of ~9 μM. |
|
V22815 | Jaceosidin | 18085-97-7 | Jaceosidin is a flavonoid obtained from Artemisia vestita, which can activate Bax, downregulate the expression of Mcl-1 and c-FLIP, and cause apoptosis of cancer/tumor cells. |
|
V2775 | Marinopyrrole A (Maritoclax) | 1227962-62-0 | Marinopyrrole A (also known as Maritoclax) is a natural product and a selective antagonist of Mcl-1 with anticancer activity. |
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V80717 | Mcl-1 inhibitor 14 | Mcl-1 inhibitor 14 (Compound (Ra)-10) is an inhibitor (blocker/antagonist) of myeloid cell leukemia-1 (MCL-1) with a Ki of 0.018 nM and may be utilized in anti-cancer research. | |
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V80718 | Mcl-1 inhibitor 15 | Mcl-1 inhibitor 15 (Compound (Ra)-15) is a Mcl-1 inhibitor (Ki: 0.02 nM). | |
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V78856 | Mcl-1 inhibitor 16 | Mcl-1 inhibitor 16 (Compound 9) is a platinum-based mitochondrial-targeting Mcl-1 inhibitor. | |
|
V76048 | Mcl-1 inhibitor 17 | 892250-00-9 | Mcl-1 inhibitor 17 is a Mcl-1 protein inhibitor. |
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V51321 | Mcl-1 inhibitor 6 | 2598978-56-2 | myeloid cell leukemia 1 (Mcl-1) inhibitor |
|
V51645 | MCL-1/BCL-2-IN-2 | 2163793-44-8 | MCL-1/BCL-2-IN-2 (Compound 6) is a potent and specific inhibitor of Mcl-1 and Bcl-2. |
|
V14901 | Mcl1-IN-2 | 292057-76-2 | IMB-XH1 is a myeloid cytokine 1 (Mcl-1) inhibitor. |
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V0003 | Navitoclax (ABT-263) | 923564-51-6 | Navitoclax (formerly ABT-263) is a novel, highly potent,orally bioavailable small-molecule inhibitor of the BCL (B-cell leukemia) protein family such as Bcl-xL, Bcl-2 and Bcl-w with Ki of ~ 0.5 nM, ~1 nM and ~1 nM in cell-free assays. |
|
V0004 | Obatoclax Mesylate (GX15-070) | 803712-79-0 | Obatoclax Mesylate (also known as GX15 070), the mesylate salt of obatoclax, is a potent inhibitor of Bcl-2 (B-cell leukemia protein-2) protein with a Ki of 0.22 μM in a cell-free assay. |
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