A family of proteins known as Bcl-2 have evolutionary connections. These proteins, which include Bcl-2 proper, Bcl-xL, and Bcl-w among a variety of others, control mitochondrial outer membrane permeabilization (MOMP). They can either be pro- or anti-apoptotic. The Bcl-2 family comprises a total of 25 known genes. These human genes include Bak1, Bax, Bal-2, Bok, and Mcl-1, which code for members of this family of proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V80227 | Oblimersen sodium | Oblimersen sodium is an inhibitor (blocker/antagonist) of BCL-2 RNA. | |
|
V76580 | PUMA BH3 | PUMA BH3 is a p53 positive regulator of apoptosis (PUMA) BH3 domain-containing polypeptide, which works as a direct activator of Bak with a Kd of 26 nM. | |
|
V81255 | PUMA BH3 TFA | PUMA BH3 TFA is a p53 positive regulator of apoptosis (PUMA) BH3 domain-containing polypeptide, which works as a direct activator of Bak with a Kd of 26 nM. | |
|
V7551 | Pyridoclax (MR29072) | 1651890-44-6 | Pyridoclax, formerly known as MR29072, is a potent and selective Mcl-1 inhibitor. |
|
V81269 | r8 Bid BH3 | r8 Bid BH3 is a biologically active peptide. | |
|
|
V81325 | Rosomidnar sodium (PNT100 sodium) | PNT100 sodium is an unmodified DNA oligonucleotide sequence that is complementary to the upstream regulatory region of the BCL-2 gene, inhibiting tumor cell proliferation/growth and inducing cell death. | |
|
V4116 | S55746 | 1448584-12-0 | S55746 (formerly known as S-055746 and BCL201) is a novel, potent, selective and orally bioactiveBCL-2 inhibitor with Ki of 1.3 nM. |
|
V2797 | S63845 | 1799633-27-4 | S63845 is a potent, selective and high affinity small molecule inhibitor of MCL1 (myeloid cell leukemia 1) with Ki value < 1.2 nM. |
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V2800 | S63845 TFA | 1799633-27-4 | S63845 TFA, the Trifluoroacetic acid salt of S63845, is a potent, selective small molecule inhibitor of MCL1 (myeloid cell leukemia 1) with Ki value < 1.2 nM. |
|
V5242 | S64315 (MIK665) | 1799631-75-6 | MIK665 (also known asMIK-665; S-64315) is a novel, investigational and specific Mcl-1 inhibitor with an IC50of 1.81 nM. |
|
V0008 | sabutoclax (BI 97C1) | 1228108-65-3 | Sabutoclax (BI-97C1),a derivative of apogossypolone, is a novel and potent pan-Bcl-2 inhibitor with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM forBcl-xL, Bcl-2, Mcl-1 and Bfl-1, respectively. |
|
V15950 | TCPOBOP | 76150-91-9 | TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver damage or tissue loss. |
|
V0005 | tw-37 | 877877-35-5 | TW-37 (TW37 or TW 37) is a novel and potent small-molecule inhibitor of Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively. |
|
V0009 | UMI-77 | 518303-20-3 | UMI-77 (UMI 77; UMI77) is a novel, potent and selective Mcl-1 (Myeloid cell leukemia-1) inhibitor with Ki of 490 nM. |
|
V81668 | UMI-77-d4 | UMI-77-d4 is the deuterium labelled form of UMI-77. | |
|
V79089 | VEGFR-2-IN-36 | VEGFR-2-IN-36 (compound 15) is a VEGFR-2 inhibitor (IC50= 0.067 μM) and apoptosis inducer with anti-cancer activity. | |
|
V0001 | Venetoclax (ABT-199; GDC-0199) | 1257044-40-8 | Venetoclax (formerly known as ABT-199 or GDC-0199; Venclexta) is a potent, selective andorally bioavailablesmall molecule inhibitor of theanti-apoptotic protein BCL-2 (B-cell lymphoma-2) with Ki of<0.01 nM. |
|
V28116 | VU661013 | 2131184-57-9 | VU661013 is a novel and potent MCL-1 Inhibitor combining with Venetoclax for rescuing Venetoclax Resistant Acute Myelogenous Leukemia. |
|
V3176 | WEHI-539 | 1431866-33-9 | WEHI-539 is a potent and selective inhibitor of BCL-XLwith IC50value of 1.1 nM. |
|
V2772 | WEHI-539 hydrochloride | 2070018-33-4 | WEHI-539 hydrochloride, the HCl salt ofWEHI-539, is a potent and selective inhibitor of BCL-XLwith IC50value of 1.1 nM. |
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