| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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| Targets |
BDK (IC50 = 3.19 μM); Mcl-1 (IC50 = 59 μM)
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|---|---|
| ln Vivo |
BT2 (20 mg/kg/day; intraperitoneal injection; daily; for 7 days; C57BL/6J male mice) treatment significantly increases BCKDC activity in the heart (12.3-fold) when compared to vehicle-treated animals. At 3.6 and 3.8 times, respectively, less activation is obtained in the kidney and muscle. The decreased phosphorylation in the heart, muscle, and kidney following the long-term BT2 treatment is correlated with the -fold activation of BCKDC activity in the aforementioned tissues. Protein levels of BDK are lowered in the kidneys and heart after BT2 treatment[1].
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| References |
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| Molecular Formula |
C9H4CL2O2S
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|---|---|
| Molecular Weight |
247.08
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| Exact Mass |
245.9309
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| Elemental Analysis |
C, 43.75; H, 1.63; Cl, 28.69; O, 12.95; S, 12.98
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| CAS # |
34576-94-8
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| Related CAS # |
34576-94-8
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| Appearance |
Solid powder
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| SMILES |
C1=CC2=C(C=C1Cl)SC(=C2Cl)C(=O)O
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| InChi Key |
AAHPIJMQJAZYTM-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H4Cl2O2S/c10-4-1-2-5-6(3-4)14-8(7(5)11)9(12)13/h1-3H,(H,12,13)
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| Chemical Name |
3,6-dichloro-1-benzothiophene-2-carboxylic acid
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| Synonyms |
BT2; BT 2; BT-2
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 49~62.5 mg/mL(198.3~252.9 mM)
Ethanol: ~3 mg/mL (~12.1 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (8.42 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (8.42 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0473 mL | 20.2364 mL | 40.4727 mL | |
| 5 mM | 0.8095 mL | 4.0473 mL | 8.0945 mL | |
| 10 mM | 0.4047 mL | 2.0236 mL | 4.0473 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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