The genetic material (DNA or RNA) of viral pathogens contains enzymes called viral proteases. Viral proteases catalyze the cleavage of particular peptide bonds in cellular proteins or viral polyprotein precursors. Viral proteases may attack the scissile peptide bond using various catalytic mechanisms involving either serine, cysteine, or aspartic acid residues. A high degree of specific recognition and cleavage is guaranteed by the enzyme's complementary substrate binding site's selective recognition of these sequence patterns.
The respiratory illness coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 coronavirus (SARS-CoV-2). SARS-CoV-2 entry requires transmembrane protease, serine 2 (TMPRSS2) to prime the initial spike protein. The cell's protease TMPRSS2 breaks open the virus's spike protein after a SARS-CoV-2 virion attaches to a target cell, revealing a fusion peptide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1907 | ESI-09 | 263707-16-0 | ESI-09 (ESI09) is a non-noncyclic nucleotide and specific inhibitor of exchange protein directly activated by cAMP (EPAC) with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively. |
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V54442 | Flaviviruses-IN-2 | 1009762-84-8 | Flaviviruses-IN-2 (compound 78) is a potent inhibitor of flaviviruses. |
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V52973 | Flaviviruses-IN-3 | 420090-97-7 | Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruses. |
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V79718 | HCVcc-IN-1 | HCV (hepatitis C virus)cc-IN-2 is a benzothiazole-2-thiophene S-glycoside analogue with low toxicity and anti-viral effect. | |
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V78142 | HCVcc-IN-2 | HCV (hepatitis C virus)cc-IN-2 is a benzothiazole-2-thiophene S-glycoside analogue with antitumor and antiviral effect. | |
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V54446 | Herpes virus inhibitor 1 | 103424-73-3 | Herpes virus inhibitor 1 is a herpes virus inhibitor that disrupts the quaternary structure of herpes virus ribonucleotide reductase. |
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V51886 | LabMol-301 | 1360243-08-8 | LabMol-301 inhibits the activity of NS5 RdRp and NS2B-NS3pro (IC50 of 0.8 and 7.4 μM, respectively). |
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V51885 | LabMol-319 | 381188-63-2 | LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor (antagonist) with IC50 of 1.6 μM. |
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V3753 | ML414 (NGI-1) | 790702-57-7 | ML414 (also known NGI-1) is a novel and cell-permeable inhibitor of oligosaccharyltransferase (OST), which is a hetero-oligomeric enzyme that exists in multiple isoforms and transfers oligosaccharides to recipient proteins. |
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V54166 | Mosnodenvir (JNJ-1802) | 2890688-86-3 | Mosnodenvir (JNJ-1802) is a pan-serotype dengue antiviral drug with a high resistance barrier that is safe and well tolerated. |
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V76096 | Mosnodenvir (JNJ-1802) | 2043343-94-6 | Mosnodenvir (JNJ-1802) is a pan-serotype dengue antiviral drug with a high resistance barrier that is safe and well tolerated. |
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V52689 | N-Desmethylclozapine-d8 (Norclozapine-d8; Desmethylclozapine-d8; Normethylclozapine-d8) | 1189888-77-4 | N-Desmethylclozapine-d8 is the deuterated form of N-Desmethylclozapine. |
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V52688 | N-Desmethylclozapine-d8 hydrochloride (Norclozapine-d8 hydrochloride; Desmethylclozapine-d8 hydrochloride; Normethylclozapine-d8 hydrochloride) | 2705402-91-9 | N-Desmethylclozapine-d8 ( HCl) is the deuterated form of N-Desmethylclozapine HCl. |
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V41103 | NITD-688 | 2407227-31-8 | NITD-688 is an orally bioactive, pan-serotype inhibitor of the dengue virus NS4B protein. |
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V78729 | NS2B-NS3pro-IN-1 | NS2B-NS3pro-IN-1 is a potent inhibitor of the Zika Virus NS2B-NS3 protease with EC50 of 50 μM and plays an important role in the Zika Virus (ZIKV) cycle. | |
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V78791 | NS2B-NS3pro-IN-2 | NS2B-NS3pro-IN-2 is an inhibitor (blocker/antagonist) of Zika virus NS2B-NS3 protease. | |
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V76097 | NS2B/NS3-IN-3 | 2832876-90-9 | NS2B/NS3-IN-3 (Compd 66) is an inhibitor (blocker/antagonist) of the Flavivirus NS2B-NS3 protease. |
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V41096 | NS2B/NS3-IN-3 hydrochloride | 2832876-91-0 | NS2B/NS3-IN-3 HCl is an inhibitor (blocker/antagonist) of Flavivirus NS2B-NS3 protease. |
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V76098 | NS2B/NS3-IN-4 | 2910757-30-9 | NS2B/NS3-IN-4 (Compound 34e) is an allosteric inhibitor of DENV2 and ZIKV NS2B/NS3 proteases with IC50s of 0.69 µM and 1.04 µM for DENV2 and ZIKV NS2B/NS3 proteases, respectively. |
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V76100 | NS2B/NS3-IN-5 | 2910757-21-8 | NS2B/NS3-IN-5 (Compound 25b) is an allosteric inhibitor of DENV2 and ZIKV NS2B/NS3 proteases with IC50s of 0.67 µM and 4.38 µM for ZIKV and DENV2 NS2B/NS3 proteases, respectively. |
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