The genetic material (DNA or RNA) of viral pathogens contains enzymes called viral proteases. Viral proteases catalyze the cleavage of particular peptide bonds in cellular proteins or viral polyprotein precursors. Viral proteases may attack the scissile peptide bond using various catalytic mechanisms involving either serine, cysteine, or aspartic acid residues. A high degree of specific recognition and cleavage is guaranteed by the enzyme's complementary substrate binding site's selective recognition of these sequence patterns.
The respiratory illness coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 coronavirus (SARS-CoV-2). SARS-CoV-2 entry requires transmembrane protease, serine 2 (TMPRSS2) to prime the initial spike protein. The cell's protease TMPRSS2 breaks open the virus's spike protein after a SARS-CoV-2 virion attaches to a target cell, revealing a fusion peptide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54447 | NSC 288387 | 61369-43-5 | NSC 288387 is a panflaviviral MTase inhibitor. |
|
V52655 | Phenytoin-15N2,13C (Phenytoin-15N2,13C) | 78213-26-0 | Phenytoin-15N2,13C is 13C (carbon 13) and 15N (nitrogen 15) labelled phenytoin. |
|
V52654 | Phenytoin-d10 (5,5-Diphenylhydantoin-d10) | 65854-97-9 | Phenytoin-d10 is the deuterium labelled form of Phenytoin. |
|
V53253 | Policies | 101418-00-2 | Polircresulen is a potent DENV2 NS2B/NS3 protease inhibitor (IC50 is 0.48 μg/mL). |
|
V52682 | Probucol-13C3 (Probucol-13C3) | 1173019-29-8 | Probucol-13C3 is a 13C (carbon 13)-labeled Probucol. |
|
V14128 | Rupintrivir (AG7088) | 223537-30-2 | Rupintrivir (AG-7088) is a novel, selective and irreversible rhinovirus 3C protease inhibitor potentially for the treatment of human rhinovirus-HRV infection. |
|
V36591 | SID-852843 | 909859-19-4 | SID-852843 is a WNV NS2B-NS3 protease inhibitor. |
|
V76099 | SP-471 | 2768010-39-3 | SP-471 is a potent dengue virus (DENV) protease inhibitor (antagonist) with IC50 of 18 μM. |
|
V79632 | Wulfenioidin F | Wulfenioidin F is a diterpenoid that can be extracted from the whole plant of Orthosiphon wulfenioides. | |
|
V77892 | β-Herpesvirus protease-IN-1 | β-Herpesvirus protease-IN-1 (compound 19) is a β-herpesvirus protease inhibitor (antagonist) with IC50 of 2.5 μM and 0.33 μM for HCMVPro and HHV6Pro respectively. |
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