Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
PP1 (known also as EI275; EI-275; PP-1; PP 1; AG1872; AG-1872) is a novel, potent and selective Src kinase inhibitor with potential antitumor activity. It inhibits Lck/Fyn kinases with IC50 of 5 nM/6 nM. It exhibits excellent anti-proliferative activity in vitro and high in vivo antitumor efficacy.
ln Vitro |
In vitro, PP1 exhibits much lower doses of inhibition against Lck (IC50=5 nM) and FynT (IC50=6 nM) than against ZAP-70 (IC50>100 μM), JAK2 (IC50>50 μM), EGFR, and protein A. In human T cells, PP1 inhibits the production of the IL-2R gene and GM-CSF-induced IL-2 gene [1].
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ln Vivo |
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Animal Protocol |
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References |
[1]. Hanke JH, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem. 1996 Jan 12;271(2):695-701
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Molecular Formula |
C16H19N5
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Molecular Weight |
281.36
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CAS # |
172889-26-8
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SMILES |
NC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(C)C=C3)=NC=N1
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.5542 mL | 17.7708 mL | 35.5417 mL | |
5 mM | 0.7108 mL | 3.5542 mL | 7.1083 mL | |
10 mM | 0.3554 mL | 1.7771 mL | 3.5542 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.