Protein kinase C, or PKC, is a family of enzymes that phosphorylates the hydroxyl groups of serine and threonine amino acid residues on proteins to regulate the activity of other proteins. Signals like an increase in the concentration of calcium ions (Ca2+) or diacylglycerol (DAG) can also activate PKC enzymes. PKC enzymes thus play crucial roles in a number of signal transduction cascades.The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC participates in the desensitization of receptors, modulation of membrane structure events, transcriptional regulation, mediating immune responses, control of cell growth, learning, and memory. Other proteins are phosphorylated to carry out these functions by PKC.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V77094 | Delcasertib hydrochloride (KAI-9803 hydrochloride; BMS-875944 hydrochloride) | Delcasertib (KAI-9803) HCl is a specific inhibitor of delta protein kinase C (delta PKC). | |
|
V1529 | Dequalinium Chloride | 522-51-0 | Dequalinium Chloride (Dequavagyn;NSC-166454; NSC166454) is a potent PKC (protein kinase C) inhibitor with potential antitumor activity. |
|
V1522 | Enzastaurin (LY317615) | 170364-57-5 | Enzastaurin (formerly known as LY317615; DB-102;DB102 and LY-317615) is a novel, potent, and selective inhibitor of PKCβ (Protein kinase C) with potential antitumor activity. |
|
V56113 | ɛPKC(85–92),Myristoylated | 1072301-79-1 | PKC(85-92), Myristoylated, is a cell-permeable (penetrable) myristic acid-conjugated PKC® peptide activator that promotes NO release from cultured human umbilical vein endothelial cells (HUVECs). |
|
V52113 | Epsilon-V1-2 (ε-V1-2; EAVSLKPT) | 182683-50-7 | Epsilon-V1-2 (ε-V1-2) is a PKCε-derived peptide and a selective PKCε inhibitor. |
|
V79324 | Epsilon-V1-2, Cys-conjugated | Epsilon-V1-2, Cys-conjugated is a biologically active peptide. | |
|
V1525 | Go 6983 | 133053-19-7 | Go 6983 (also known as GOE-6983;Go-6983;GOE6983;Go6983) is a novel and potent pan-PKC (protein kinase C) inhibitor with potential anticancer and cardioprotective activity. |
|
V80667 | Malantide TFA | Malantide TFA is a synthetic dodecapeptide extracted from a site phosphorylated by PKA on the beta subunit of phosphorylase kinase. | |
|
V1527 | Midostaurin (PKC412) | 120685-11-2 | Midostaurin (formerly also known as PKC-412;CGP41251;PKC412;CGP 41251;PKC 412; PKC412A; trade name:Rydapt),a synthetic indolocarbazole compound, is a multi-targeted kinase inhibitor with potential with potential antiangiogenic and antineoplastic activities. |
|
V76735 | Myelin Basic Protein TFA (MHP4-14 TFA) | Myelin Basic Protein (MHP4-14) TFA is a synthetic peptide containing residues 4-14 of myelin basic protein and is a very selective PKC substrate (Km=7 μM). | |
|
V1530 | Myricitrin | 17912-87-7 | Myricitrin (Myricitroside), a naturally occurring flavonoid compound isolated from the root bark of Myrica cerifera, is a bioactive compound which exerts antinociceptive effects. |
|
V4796 | Oncrasin-1 | 75629-57-1 | Oncrasin-1 is a novel and potent antitumor agent that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; it also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells. |
|
V41020 | Pep2m, myristoylated (Myr-Pep2m) | 1423381-07-0 | Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable (penetrable) peptide. |
|
V76643 | Pep2m, myristoylated TFA (Myr-Pep2m TFA) | Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable (penetrable) peptide. | |
|
V34806 | Phosphate acceptor peptide | 93511-94-5 | Phosphate acceptor peptide is a substrate of cAMP-dependent protein kinase (PKA). |
|
V81153 | PKC 20-28,myristoylated (Myristoylated protein kinase C inhibitor 20-28) | PKC 20-28,myristoylated (Myristoylated protein kinase C inhibitor 20-28) is a cell-permeable (penetrable) PKC inhibitor. | |
|
V81154 | PKC β pseudosubstrate TFA | PKC β pseudosubstrate TFA is a selective, cell-penetrable PKC inhibitor. | |
|
V53320 | PKC-iota inhibitor 1 | 2328094-11-5 | PKC-iota inhibitor 1 (compound 19) is a protein kinase C-iota (PKC-iota) inhibitor (antagonist) with IC50 of 0.34 μM. |
|
V81157 | PKC-ε translocation inhibitor peptide | PKC-ε translocation inhibitor peptide is a PKC-ε translocation inhibitor. | |
|
V56107 | PKCiota-IN-1 | 2230052-97-6 | PKCiota-IN-1 (compound 51) is a potent inhibitor of PKCiota (PKC-ι) with IC50 of 2.7 nM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
