Protein kinase C, or PKC, is a family of enzymes that phosphorylates the hydroxyl groups of serine and threonine amino acid residues on proteins to regulate the activity of other proteins. Signals like an increase in the concentration of calcium ions (Ca2+) or diacylglycerol (DAG) can also activate PKC enzymes. PKC enzymes thus play crucial roles in a number of signal transduction cascades.The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC participates in the desensitization of receptors, modulation of membrane structure events, transcriptional regulation, mediating immune responses, control of cell growth, learning, and memory. Other proteins are phosphorylated to carry out these functions by PKC.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V76626 | PKCiota-IN-2 formic | PKCiota-IN-2 formic is a potent inhibitor of PKCiota (PKC-ι) with IC50 of 2.8 nM. | |
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V81155 | PKCα (C2-4) inhibitor peptide | PKCα (C2-4) inhibitor peptide is a PKCα-specific inhibitor peptide that blocks the inhibitory effect of α1A-adrenergic receptor agonist A-61603 on IKr. | |
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V81156 | PKCε inhibitor peptide,myristoylated (Myr‐PKCɛ-) | PKCε inhibitor peptide,myristoylated (Myr‐PKC?-) is a cell-permeable (penetrable) myristic acid-conjugated PKC? peptide inhibitor that attenuates NO release from cultured human umbilical vein endothelial cells (HUVECs). | |
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V81158 | PKCθ pseudosubstrate peptide inhibitor,myristoylated | PKCθ pseudosubstrate peptide inhibitor, myristoylated is a synthetic peptide that may be utilized to study the mechanism of action of PKCθ. | |
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V81237 | Protein Kinase C (19-31) (TFA) (PKC (19-31) (TFA)) | Protein Kinase C (19-31) TFA is an inhibitor (blocker/antagonist) of protein kinase C (PKC). | |
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V34692 | Protein Kinase C (19-35) Peptide | 309247-48-1 | Protein Kinase C (19-35) Peptide is a PKC pseudosubstrate inhibitor/domain. |
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V56108 | Protein Kinase C (660-673) (PKC βII (660-673)) | 149839-94-1 | Protein Kinase C (660-673) (PKC βII (660-673)) is a PKC βII V5 peptide with RACK1 binding affinity. |
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V56103 | Protein Kinase C (661-671) | 149839-93-0 | Protein Kinase C (661-671) is a fragment peptide of the β1 subspecies of protein kinase C (PKC). |
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V56102 | Protein Kinase C β Peptide | 309247-50-5 | Protein Kinase C β Peptide is a polypeptide fragment of Protein Kinase Cβ. |
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V56297 | Protein Kinase C | Peptide | 309247-51-6 | Protein Kinase C γ Peptide is a bioactive peptide fragment of Protein Kinase C γ. |
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V11333 | R 59949 | 120166-69-0 | R59949 is a pan-diacylglycerol kinase (DGK) inhibitor (antagonist) with IC50 of 300 nM. |
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V2682 | Ro 31-8220 | 125314-64-9 | Ro 31-8220 is a novel and potent pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1. |
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V1528 | Ro 31-8220 Mesylate | 138489-18-6 | Ro 31-8220 mesylate (RO31-8220;BIM IX;RO-31-8220;Bisindolylmaleimide IX;RO-318220), the mesylate salt of Ro 31-8220, is a novel and potent pan-PKC inhibitor with potential anticancer activity. |
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V5106 | Rottlerin (Mallotoxin; NSC 56346; NSC 94525) | 82-08-6 | Rottlerin (NSC-56346; NSC-94525), a naturally occuring compound isolated fromMallotus Philippinensiswith the potential to be used as a chemotherapeutic agent for adrenocortical carcinoma, is a novel and specific protein kinase C (PKC) inhibitor with IC50values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. |
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V52676 | Ruboxistaurin-d6 hydrochloride | 1794767-04-6 | Ruboxistaurin-d6 ( HCl) is the deuterated form of Ruboxistaurin HCl. |
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V76534 | SAMβA TFA | SAMβA TFA binds to the cell-permeable (penetrable) peptide TAT47-57. | |
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V1523 | Sotrastaurin (AEB071) | 425637-18-9 | Sotrastaurin (also known as AEB-071; AEB071; AEB 071) is an orally bioavailable, potent and selective pan-PKC inhibitor with potential antineoplastic activity. |
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V1524 | Staurosporine (AM-2282) | 62996-74-1 | Staurosporine (formerly also known as antibiotic AM-2282; CCRIS 3272; CGP 41251or STS) is a naturally occuring, potent and non-selectivePKC inhibitor with anti-fungal to anti-hypertensive effects. |
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V4159 | TAS-301 | 193620-69-8 | TAS-301 is a novel, potent and selective inhibitor of smooth muscle cell migration and proliferation and inhibits intimal thickening after balloon injury to rat carotid arteries. |
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V81538 | TAT-SAMβA | TAT-SAMβA is a bioactive peptide consisting of RNAENFDRF (SAMβA) combined with the cell-penetrable TAT protein-derived peptide TAT47-57. |
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