Protein kinase C, or PKC, is a family of enzymes that phosphorylates the hydroxyl groups of serine and threonine amino acid residues on proteins to regulate the activity of other proteins. Signals like an increase in the concentration of calcium ions (Ca2+) or diacylglycerol (DAG) can also activate PKC enzymes. PKC enzymes thus play crucial roles in a number of signal transduction cascades.The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC participates in the desensitization of receptors, modulation of membrane structure events, transcriptional regulation, mediating immune responses, control of cell growth, learning, and memory. Other proteins are phosphorylated to carry out these functions by PKC.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V21360 | Valrubicin | 56124-62-0 | Valrubicin is a semisynthetic analogue of the antineoplastic anthracycline antibiotic doxorubicin. |
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V56106 | Vanicoside A | 155179-22-9 | Vanicoside A is a protein kinase C (PKC) inhibitor from Polygonum pensylvanicum. |
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V53277 | Z-Arg-SBzl | 88253-86-5 | Z-Arg-SBzl is a substrate for bovine and human activin C. |
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V79190 | Z-Arg-SBzl TFA | Z-Arg-SBzl TFA is a substrate for bovine and human activin C. | |
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V53291 | ZIP | 863987-12-6 | ZIP is a selective PKMζ peptide inhibitor. |
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