Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V11666 | Gaboxadol HCl (Lu 02-030; THIP; OV101; Lu-02-030; MK 0928) | 85118-33-8 | Gaboxadol (Lu-02030, THIP, OV-101; Lu-02-030; MK-0928) is a potent GABA agonist. |
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V1293 | Ginkgolide A (BN-52020) | 15291-75-5 | Ginkgolide A (Ginkgolide A;BN 52020; BN-52020), a naturally occuring terpenic lactone isolated from Ginkgo biloba, is a g-aminobutyric acid (GABA) receptor antagonist with important biological activity. |
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V9162 | Glabridin | 59870-68-7 | Glabridin is an isoflavane extracted from Glycyrrhiza uralensis and can bind and activate PPARγ with EC50 of 6115 nM. |
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V4961 | Guvacine HCl | 6027-91-4 | Guvacine HCl, the hydrochloride salt of Guvacine, is an alkaloid isolated from the nut ofAreca catechu whichacts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). |
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V2932 | Imepitoin | 188116-07-6 | Imepitoin, formerly known as AWD 131-138 and ELB 138, is a novel partial BZD (benzodiazepine) receptor agonist that has the potential use as an antiepileptic drug for the treatment of canine idiopathic epilepsy. |
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V13578 | L-655708 | 130477-52-0 | L-655708 (FG-8094) is a novel and potent nootropic agent that acts as a subtype-selective inverse agonist at the α5 subtype of the benzodiazepine binding site on the GABAA receptor (Ki=0.45 nM). |
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V3150 | L-Cycloserine | 339-72-0 | L-cycloserine is an irreversible inhibitor of the GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. |
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V1288 | Nefiracetam (DM9384; DZL-221) | 77191-36-7 | Nefiracetam (DZL-221; DM9384; DZL221; DM 9384; Translon)is a potent GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions. |
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V1289 | Nifedipine (BAY-a-1040) | 21829-25-4 | Nifedipine (Adalat, Procardia, Bay-1040,BAY-a-1040;Cordipin, Corinfar, Bay 1040) is a dihydropyridine calcium channel blocker (CCB) with antihypertensive effects. |
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V2899 | NS-11394 | 951650-22-9 | NS11394 is a potent, selective and novel positive allosteric modulator of GABA(A) receptor. |
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V4679 | ONO-8590580 | 1802661-73-9 | ONO-8590580 is a novel and potent GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models. |
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V4434 | Pipequaline | 77472-98-1 | Pipequaline (also known as PK-8165; PK 8165),a quinoline derivative and a ligand of the benzodiazepine binding site, is a clinically-effective anxiolytic, which is devoid of sedative and anticonvulsant properties, but it was never marketed. |
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V13575 | rac-BHFF | 123557-91-5 | rac-BHFF is a potent, orally bioactive, isomeric enhancer of GABAB receptors. |
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V0049 | SSD114 HCl | 2319790-02-6 | SSD114 HCl is a novel positive allosteric modulator (PAM) of GABAB receptors. |
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V33761 | Tiagabine | 115103-54-3 | Tiagabine (NO329;NNC-050328;NO 329; NNC-05-0328; NO-05-0328; trade name Gabitril) is a selective and potent GABA (gamma-aminobutyric acid) reuptake inhibitorwith anti-convulsive activity. |
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V15214 | Valnoctamide | 4171-13-5 | Valnoctamide (Valmethamide) is an analogue of Valproate that may be used to be utilized in study/research of epilepsy that is resistant to benzodiazepine active molecules. |
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V33017 | Vigabatrin Hydrochloride | 1391054-02-6 | Vigabatrin hydrochloride (γ-Vinyl-GABA; Sabril) is an oral and structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. |
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V2688 | Zuranolone (SAGE-217) | 1632051-40-1 | This product is discontinued due to commercial reason. |
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