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    Pipequaline
    Pipequaline

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4434
    CAS #: 77472-98-1Purity ≥98%

    Description: Pipequaline (also known as PK-8165; PK 8165), a quinoline derivative and a ligand of the benzodiazepine binding site, is a clinically-effective anxiolytic, which is devoid of sedative and anticonvulsant properties, but it was never marketed. It  is a partial benzodiazepine receptor agonist with anxiolytic activity and possesses a novel chemical structure that is not closely related to other drugs of this type. TPK 8165, applied microiontophoretically or administered i.v. at low doses, suppressed CCK-8S-induced activation of hippocampal pyramidal neurons, whereas, at high doses it antagonized the effect of microiontophoretic applications of flurazepam. These results indicate that PK 8165 acts as a mixed agonist-antagonist at BZD receptors and suggest that the suppression of CCK-8S-induced activation by BZD might be related to their anxiolytic property rather than to their sedative or anticonvulsant activity.

    References: Eur J Pharmacol. 1985 Jun 19;112(3):415-8.Neuropharmacology. 1987 Sep;26(9):1337-42.


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    Pipequaline

    Name: Pipequaline
    CAS#: 77472-98-1 (free base)
    Chemical Formula: C22H24N2
    Exact Mass: 316.1939
    Molecular Weight: 316.448
    Elemental Analysis: C, 83.50; H, 7.64; N, 8.85
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PK 8165; PK-8165; PK8165.
    IUPAC/Chemical Name: 2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline
    InChi Key: AMEWZCMTSIONOX-UHFFFAOYSA-N
    InChi Code: InChI=1S/C22H24N2/c1-2-6-18(7-3-1)22-16-19(11-10-17-12-14-23-15-13-17)20-8-4-5-9-21(20)24-22/h1-9,16-17,23H,10-15H2
    SMILES Code: C1(C2=CC=CC=C2)=NC3=CC=CC=C3C(CCC4CCNCC4)=C1


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