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      Ginkgolide A (BN-52020)
      Ginkgolide A (BN-52020)

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      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V1293
      CAS #: 15291-75-5Purity ≥98%

      Description: Ginkgolide A (Ginkgolide A; BN 52020; BN-52020), a naturally occuring terpenic lactone isolated from Ginkgo biloba, is a g-aminobutyric acid (GABA) receptor antagonist with important biological activity. It inhibits GABA receptor with a Ki of 14.5 μM.  

      References: Chirality. 22 (2): 217–223; Medicinal Natural Products: A Biosynthetic Approach (3rd ed.). Wiley. pp. 230–232.

      Related CAS: 15291-75-5 (Ginkgolide A); 15291-77-7 (Ginkgolide B); 15291-76-6 (Ginkgolide C); 153355-70-5 (Ginkgolide K); 107438-79-9 (Ginkgolide J)

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      Molecular Weight (MW)408.4
      FormulaC20H24O9
      CAS No.15291-75-5
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 81 mg/mL (198.3 mM)
      Water:<1 mg/mL
      Ethanol: 2 mg/mL (4.9 mM)
      Other info

      Chemical Name: 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-

      InChi Key: FPUXKXIZEIDQKW-VKMVSBOZSA-N

      InChi Code: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1

      SMILES Code: C[[email protected]@H]1C(O[[email protected]@H]2[[email protected]@]1(O)[[email protected]@]34C(O[[email protected]]5[[email protected]@]3([[email protected]]6([[email protected]@H](O)C(O[[email protected]]6O4)=O)[[email protected]](C(C)(C)C)C5)C2)=O)=O

      SynonymsBN52020; Ginkgolide A; BN 52020; BN-52020; 


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      In Vitro

      In vitro activity: Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders. Ginkgolide A (BN-52020) failed to affect apoptotic damage neither in serum-deprived nor in staurosporine-treated neurons

      In VivoGinkgolide A significantly shortened the sleeping time in anesthetized mice
      Animal modelMice
      Formulation & DosageN/A
      References

      [1]. Wada, K., et al., Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull, 1993. 16(2): p. 210-2.

      [2]. Ahlemeyer, B. and J. Krieglstein, Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry, 2003. 36(S 1): p. 8-14.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

      Ginkgolide A
      Therapeutic effect is improved by Ginkgolide A in treating CCl4-induced hepatitis mice.


      Ginkgolide A
      Preventive effect is improved by Ginkgolide A in treating CCl4-induced hepatitis mice. Biomol Ther (Seoul). 2016 Jan;24(1):40-8. 
      		 

      Ginkgolide A

      Effect of Ginkgolide A on ALT and AST level in sera of CCl4-treated mice. Biomol Ther (Seoul). 2016 Jan;24(1):40-8. 
      		 

      Ginkgolide A

      Ginkgolide A enhanced PXR expression level in mouse liver tissue.


      Ginkgolide A

      PXR expression and histological analysis of liver and Jejunum tissue in PXR silence mice. Biomol Ther (Seoul). 2016 Jan;24(1):40-8. 

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