| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
IC50: 0.024 ± 0.012 μM (ANO1), 8.7 ± 1.0 μM (ANO2)[1]
|
|---|---|
| ln Vitro |
DFBTA exhibits extremely low levels of cardiotoxicity and cytotoxicity (IC50 > 30 μM for HEK293 proliferation and > 30 μM for hERG)[1].
|
| ln Vivo |
DFBTA has weak acute toxicity, with a minimum mouse lethal dosage (MLD) of > 1000 mg/kg in C57BL/6 mice (40-80 mg/kg, IG; 40 mg/kg, IV; once)[1]. /6 mice, 1000 mg/kg, once taken orally) exhibits good pharmacokinetic characteristics, including tiny brain penetration (<1.5% brain/plasma) and oral bioavailability > 75%[1].
|
| References |
| Exact Mass |
393.004
|
|---|---|
| CAS # |
2966044-07-3
|
| PubChem CID |
163409120
|
| Appearance |
White to off-white solid powder
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
26
|
| Complexity |
533
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CC(=CC=C1C2=CSC(=C2C(=O)O)NC(=O)C3=C(C=CC(=C3)F)F)Cl
|
| InChi Key |
RZXHOVMOLRFUCA-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C18H10ClF2NO3S/c19-10-3-1-9(2-4-10)13-8-26-17(15(13)18(24)25)22-16(23)12-7-11(20)5-6-14(12)21/h1-8H,(H,22,23)(H,24,25)
|
| Chemical Name |
4-(4-chlorophenyl)-2-[(2,5-difluorobenzoyl)amino]thiophene-3-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 8 mg/mL (20.32 mM) in 5% DMSO + 40% PEG300 + 5% Tween-80 + 50% Saline (add these co-solvents sequentially from left to right, and one by one), Suspended solution; with ultrasonication.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (6.35 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
