A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79458 | PZ-1922 | PZ-1922 (Compound 16) is a brain barrier-penetrating 5-HT6R/5-HT3R antagonist (Ki 17 nM and 0.45 nM, respectively). | |
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V2066 | RO-41-1049 hydrochloride | 127917-66-2 | Ro 41-1049 hydrochloride, the hydrochloride salt ofRo 41-1049, is a novel, potent, selective, reversible and orally bioavailable inhibitor of MAO-A (Monoamine oxidase). |
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V70651 | Rubrofusarin triglucoside | 245724-07-6 | Rubrofusarin triglucoside is a glycoside compound extracted from Cassia seeds and can inhibit human monoamine oxidase A (hMAO-A) with IC50 of 85.5 μM. |
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V70666 | Safrazine | 33419-68-0 | Safrazine is an irreversible, nonspecific MAO (monoamine oxidase) inhibitor (antagonist) with oral activity. |
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V70674 | Salsolidine hydrochloride ( Salsolidine hydrochloride; Salsolidine hydrochloride) | 63283-42-1 | Salsolidine HCl is a tetrahydroisoquinoline alkaloid that can stereoselectively and competitively inhibit the activity of MAO (monoamine oxidase) A (MAO A). |
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V70647 | SSAO inhibitor-1 | 2242883-04-9 | SSAO inhibitor-1 is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor. |
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V70667 | SWS1 | 2922115-32-8 | SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50= 1.8 nM) with anti-cancer activity. |
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V0089 | TB5 | 948841-07-4 | TB5 is a novel, potent, selective, reversible and competitive inhibitor of hMAO-B (human monoamine oxidase-B) with Kivalue of 0.11±0.01 μM. |
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V87824 | Tetrahydroharmine | 17019-01-1 | Tetrahydroharmine (Leptaflorine) is a monoamine oxidase (MAO) inhibitor with an IC50 of 74 nM for MAO-A. |
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V70659 | Tisolagiline (KDS2010) | 1894207-44-3 | Tisolagiline (KDS2010) is a reversible MAO-B inhibitor used in Parkinson's disease (PD) research. |
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V94311 | Tisolagiline methylsulfate | 1894207-45-4 | Tisolagiline methylsulfate is a reversible MAO-B inhibitor used in the study of Parkinson's disease. |
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V70680 | Tranylcypromine (SKF 385) | 155-09-9 | Tranylcypromine (SKF 385) is a potent MAO (monoamine oxidase) inhibitor. |
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V105885 | Tyramine oxidase, Microorganism | 37255-42-8 | Tyramine oxidase (EC 1.4.3.4) is a copper enzyme present in the cytoplasm of animal cells that catalyzes the oxidation of phenolamine substrates. |
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V70681 | WAY-620147 | 515866-67-8 | WAY-620147 (compound 6) is an N-(2-morpholinoethyl)nicotinamide analogue that can inhibit monoamine oxidase (Monoamine Oxidase). |
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V34351 | Obtusin | 70588-05-5 | Isolated fromCassia obtusifoliaLinn seed, Obtusin is natural product of the triterpenoid class. |
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V3149 | Iproniazid | 54-92-2 | Iproniazid (brand/other names of Marsilid, Rivivol, Euphozid, Iprazid, Ipronid, Ipronin) is a non-selective, and irreversiblemonoamine oxidase inhibitor (MAOI). |
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V60115 | Osthenol | 484-14-0 | Osthenol (Ostenol) is a pre-acetylated coumarin extracted from the dry roots of Solanum solani. |
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V18542 | Clorgyline HCl (M&B 9302, MB9302) | 17780-75-5 | Clorgyline, formerly known as Clorgiline, M&B 9302 or MB9302, is a potent,irreversible and selective inhibitor of monoamine oxidase (MAO), it is structurally related to pargyline which is described as an antidepressant. |
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V5896 | Bifemelane HCl | 62232-46-6 | Bifemelane HCl (MCI-2016) is a potent, selective and competitive inhibitor of MAO (monoamine oxidase) A (MAO-A) with Ki of 4.20 μM. |
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V25757 | Mofegiline HCl | 120635-25-8 | Mofegiline HCl(MDL-72,974; MDL72,974), the hydrochloride salt ofMofegiline, is a potent andirreversibleinhibitor of monoamine oxidase B (MAO-B) and semicarbazide-sensitive amine oxidase (SSAO)with the potential to be used for the treatment for various diseases. |
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