| Size | Price | Stock | Qty |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg | |||
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| Other Sizes |
| Targets |
Clorgyline hydrochloride targets monoamine oxidase A (MAO-A) and the sigma receptor σ1. It acts as an irreversible inhibitor of MAO-A, binding covalently to the enzyme and preventing the breakdown of monoamines such as serotonin, norepinephrine, and dopamine. It also inhibits the sigma receptor σ1 on Jurkat human T lymphocyte cells.
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| ln Vitro |
In vitro, Clorgyline hydrochloride is a potent and selective inhibitor of MAO-A. It inhibits MAO-A with a Ki of 0.054 µM and MAO-B with a Ki of 58 µM. It also inhibits the sigma receptor σ1 with an IC50 of 31 nM. By inhibiting MAO-A, it prevents the breakdown of monoamines, making it a valuable tool for studying the regulation of mood, anxiety, and neurodegenerative diseases.
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| ln Vivo |
In vivo, Clorgyline hydrochloride is used as a research tool to study the role of MAO-A in various physiological and pathological processes. It has been used in neuropharmacology and psychiatric research. By inhibiting MAO-A, it increases the levels of monoamines in the brain, which can affect mood and behavior. It is not marketed as a therapeutic agent.
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| Enzyme Assay |
Clorgyline hydrochloride is evaluated in cell-free enzymatic assays using purified MAO-A and MAO-B enzymes. The compound is incubated with the enzyme and a substrate, and the inhibition of enzyme activity is measured. IC50 and Ki values are determined to quantify the potency and selectivity of MAO-A inhibition. Sigma receptor binding assays are also performed.
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| Cell Assay |
Clorgyline hydrochloride is assessed in cell-based assays using cell lines expressing MAO-A or sigma receptors. Cells are treated with Clorgyline, and MAO-A activity is measured by assessing the metabolism of monoamines. Sigma receptor activity is assessed by measuring receptor-mediated signaling pathways.
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| Animal Protocol |
Clorgyline hydrochloride is administered in animal models to evaluate its effects on MAO-A activity and behavior. It is used to study the role of MAO-A in mood regulation, anxiety, and neurodegenerative diseases. Efficacy is assessed by measuring monoamine levels in the brain and by behavioral tests.
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| ADME/Pharmacokinetics |
Clorgyline hydrochloride has a molecular weight of 308.6 and a molecular formula of C13H15Cl2NO·HCl. It has a CAS number of 17780-75-5. The compound is a powder with a purity of ≥95%. It should be stored under recommended conditions.
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| Toxicity/Toxicokinetics |
Clorgyline hydrochloride is an irreversible inhibitor of MAO-A. No detailed toxicity data is available for this compound beyond its use as a research tool. It is for research use only and is not intended for human therapeutic use.
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| References |
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| Additional Infomation |
Clorgyline is an aromatic ether, a 2,4-dichlorophenyl ether of 3-aminoprop-1-ol, wherein the nitrogen atom is replaced by a methyl group and a prop-1-yn-3-yl group. It is a monoamine oxidase inhibitor and was formerly used as an antidepressant. It has a dual role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and an antidepressant. It is a tertiary amine compound, a terminal alkyne compound, an aromatic ether, and a dichlorobenzene.
An antidepressant and monoamine oxidase inhibitor associated with Clorgyline. An antidepressant and monoamine oxidase inhibitor associated with Clorgyline. Clorgyline hydrochloride is also known as Clorgiline hydrochloride. It is a potent σ1 receptor inhibitor. It was never marketed as a therapeutic agent, but it has found use in scientific research. It is not approved for clinical use. |
| Molecular Formula |
C13H16CL3NO
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|---|---|
| Molecular Weight |
272.1703
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| Exact Mass |
307.029
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| CAS # |
17780-75-5
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| Related CAS # |
17780-72-2;17780-75-5 (HCl);
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| PubChem CID |
4380
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| Appearance |
White to off-white solid powder
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| Boiling Point |
361.3ºC at 760mmHg
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| Flash Point |
172.3ºC
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| Vapour Pressure |
2.1E-05mmHg at 25°C
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| LogP |
4.129
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
17
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| Complexity |
263
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
BTFHLQRNAMSNLC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
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| Chemical Name |
N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine hydrochloride
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| Synonyms |
M&B 9302 MB 9302 MB-9302 MB9302Clorgyline HCl Clorgyline hydrochloride Clorgiline
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~324.01 mM)
H2O : ~100 mg/mL (~324.01 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.10 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.10 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.10 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6742 mL | 18.3709 mL | 36.7417 mL | |
| 5 mM | 0.7348 mL | 3.6742 mL | 7.3483 mL | |
| 10 mM | 0.3674 mL | 1.8371 mL | 3.6742 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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