As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71412 | β-Amyloid (1-38) (Aβ (1-38); Aβ38) | 131438-74-9 | β-Amyloid (1-38) (Aβ (1-38); Aβ38) is an Aβ fragment. |
|
V71388 | β-Amyloid (1-38), mouse, rat | 186359-66-0 | β-Amyloid (1-38), mouse, rat is a 38-amino acid (AA) polypeptide consisting of residues 1-38 of the β-Amyloid peptide. |
|
V57783 | β-Amyloid (1-40), FAM-labeled | 1678416-08-4 | β-Amyloid (1-40), FAM-labeled is a FAM fluorescently labeled β-Amyloid (1-40) peptide (λex= 492 nm and λem= 518 nm). |
|
V81807 | β-Amyloid (1-40), FAM-labeled TFA | β-Amyloid (1-40), FAM-labeled TFA is a FAM fluorescently labeled β-Amyloid (1-40) peptide (λex= 492 nm and λem= 518 nm). | |
|
V66370 | β-Amyloid (1-42), (rat/mouse) (TFA) (Amyloid β-peptide (1-42) (rat/mouse) TFA) | β-Amyloid (1-42), (rat/mouse) TFA is a 42-amino-acid polypeptide that is toxic to hippocampal slices and may be utilized in AD/Alzheimer's disease study. | |
|
V71433 | β-Amyloid (1-42), human, FAM-labeled (Amyloid β-peptide (1-42) (human), FAM-labeled) | 1802087-78-0 | β-Amyloid (1-42), human, FAM-labeled is a biologically active peptide. |
|
V71437 | β-Amyloid (1-43)(human) | 134500-80-4 | β-Amyloid (1-43)(human) is more prone to aggregation and has higher toxicity than the known Aβ1-42. |
|
V81808 | β-Amyloid (1-43)(human) TFA | β-Amyloid (1-43)(human) TFA is more prone to aggregation and has higher toxicity than the known Aβ1-42. | |
|
V71444 | β-Amyloid (1-8) | 659739-33-0 | β-Amyloid (1-8) is an Aβ fragment. |
|
V81809 | β-Amyloid (1-8, A2V) | β-Amyloid (1-8, A2V) is a mutant form of β-Amyloid (1-8). | |
|
V66290 | β-Amyloid (22-35) (TFA) (Amyloid β-Protein (22-35) (TFA)) | β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the 22-35 residue fragment of β-amyloid protein, has a cytotoxic effect on rat hippocampal neurons cultured without serum. | |
|
V71422 | β-Amyloid (40-1) | 144409-99-4 | β-Amyloid (40-1) is a biologically active peptide. |
|
V71364 | β-Amyloid peptide(16-20) (KLVFF) | 153247-40-6 | β-Amyloid peptide(16-20) is an amino acid (AA) sequence (KLVFF) of Amyloid-β (Abeta). |
|
V71429 | β-Amyloid precursor protein (96-110), cyclized (human) | 289634-54-4 | β-Amyloid precursor protein (96-110), cyclized (human) is an amyloid precursor protein. |
|
V81810 | β-Amyloid-15N (1-40) (TFA) (Amyloid Beta-Peptide-15N (1-40) (human) TFA; Amyloid β-Peptide-15N (1-40) (human) TFA) | β-Amyloid-15N (1-40) (TFA) is 15N (Nitrogen 15)-labelled β-Amyloid (1-40) (TFA). | |
|
V81811 | β-Amyloid-15N (1-42), human TFA (Amyloid β-peptide-15N (1-42) (human) TFA) | β-Amyloid-15N (1-42), human (TFA) is 15N (Nitrogen 15)-labelled β-Amyloid (1-42) (TFA). | |
|
V71366 | β-Sheet Breaker Peptide iAβ5 ([Pro18, Asp21] β-Amyloid (17-21)) | 182912-74-9 | Beta-Sheet Breaker Peptide iAβ5 is a potent brain amyloid-beta (Abeta) degrader. |
|
V71407 | γ-Secretase modulator 13 | 1353570-40-7 | γ-Secretase modulator 13 (compound 4) is a γ-secretase modulator (GSMs) that can inhibit the production of aggregated amyloid β peptide Aβ42 with IC50 of 163 nM, may be utilized in AD/Alzheimer's disease study. |
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