As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V14996 | SNU-0039 (DWK-133) | 1018946-38-7 | SNU-0039(DWK-133) is an orally bioavailable inhibitor of β-amyloid protein aggregation with the potential to be used as an anti-Alzheimers agent. |
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V71359 | Solanezumab (Immunoglobulin G1, anti-(human β-amyloid) (human-mouse monoclonAnti-Human Abeta Recombinant Antibody) | 955085-14-0 | Solanezumab is a humanized monoclonal IgG1 antibody directed against the middle domain of the amyloid-β (Aβ) peptide. |
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V79665 | SQ-3 | SQ-3 is a quinoline analogue with moderate selectivity for α-syn aggregates (Ki=39.3 nM) and over β-amyloid (Aβ) aggregates with Ki of 39.3 nM and 230 nM respectively. | |
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V9037 | Tabersonine | 4429-63-4 | Tabersonine is a naturally occuring terpene indole alkaloid extracted from the medicinal plant Catharanthus roseus and also in the genus Voacanga. |
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V81539 | tau/Aβ40 aggregation-IN-1 | tau/Aβ40 aggregation-IN-1 (Compound 20) is an inhibitor (blocker/antagonist) of tau and Aβ40 aggregation with IC50 of 1.8 μM and 1.3 μM respectively. | |
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V71361 | Tramiprosate-d6 (Homotaurine-d6; 3-Amino-1-propanesulfonic acid-d6) | 1131576-06-1 | Tramiprosate-d6 is the deuterated form of Tramiprosate. |
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V71373 | Trontinemab | 2568868-35-7 | Trontinemab is a bispecific human IgG1-κ antibody targeting amyloid beta A4 precursor protein (APP) and transferrin receptor p90, CD71 (TFRC). |
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V16894 | TRX-0237 mesylate | 1236208-20-0 | TRX-0237 mesylate (LMT-X; TRX0237;Leuco-MTx; LMTX; Hydromethylthionine mesylate), the mesylate salt ofTRX 0237 which is currentlyin phase III clinical trials by TauRx,is a 2nd-generation tau protein aggregation and TDP-43 aggregation inhibitor with the potential for the treatment of Alzheimers disease (AD) and frontotemporal dementia. |
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V71400 | YIAD-0205 | 2446054-34-6 | YIAD-0205 is an orally bioactive Aβ(1?42) aggregation inhibitor. |
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V71404 | β Amyloid (1-16) rat | 1123154-43-7 | β-Amyloid (1-16) rat is a β-amyloid peptide (Abeta), a metal-binding domain fragment of amyloid protein. |
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V71435 | β Amyloid (1-39) | 115427-62-8 | β Amyloid (1-39) is an Aβ fragment. |
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V71401 | β Amyloid (1-42) (scrambled) | 1678415-52-5 | β Amyloid (1-42) (scrambled) is a control of β-Amyloid (1-42), human TFA. |
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V71375 | β Amyloid (11-42) | 157802-70-5 | β Amyloid (11-42) is an Aβ fragment. |
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V71387 | β Amyloid (3-40) | 157884-70-3 | β Amyloid (3-40) is an Aβ fragment. |
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V81799 | β Amyloid(17-28) human | β Amyloid(17-28) human is a β-amyloid peptide (Abeta), a lipid-induced amyloid core fragment. | |
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V71436 | β Amyloid(28-35)human | 182945-56-8 | β Amyloid(28-35) human is a β-amyloid peptide (Abeta), a lipid-induced amyloid core fragment. |
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V81806 | β-Amyloid (1-14),mouse,rat | β-Amyloid (1-14),mouse,rat is the 1-14 fragment of the Amyloid-β polypeptide. | |
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V66652 | β-Amyloid (1-19) (acetate) | β-Amyloid (1-19) acetate is the acetate salt form of β-Amyloid (1-19) and consists of amino acid (AA)s 1-19 of β-Amyloid. | |
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V66601 | β-Amyloid (1-20) (acetate) | β-Amyloid (1-20) acetate is the acetate salt form of β-Amyloid (1-20) and consists of amino acid (AA)s 1-20 of β-Amyloid. | |
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V71421 | β-Amyloid (1-37) (human) | 186359-67-1 | β-Amyloid (1-37) (human) is highly correlated with AD/Alzheimer's disease Mental State Examination (MMSE) scores. |
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