As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71376 | Aβ42 agonist-2 | 6314-40-5 | Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. |
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V71360 | Bapineuzumab | 648895-38-9 | Bapineuzumab is an anti-β-amyloid (APP) monoclonal antibody (mAb). |
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V4468 | Bavachinin (BVC; 7-O-Methylbavachin; Bavachinin A) | 19879-30-2 | Bavachinin(BVC; 7-O-Methylbavachin; Bavachinin A) is a naturally occuring compound isolated from the fruit of the traditional Chinese herb Fructus Psoraleae (FP). |
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V71445 | Beta-Amyloid (15-21) (Beta-Amyloid (15-21)) | 365537-52-6 | β-amyloid (15-21) is a fragment of the β-amyloid peptide with potential role in the neurological field. |
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V71413 | BIBD-124 | 2716871-93-9 | BIBD-124 binds amyloid (Aβ) plaques with IC50 of 9.51 nM. |
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V71405 | Biotin-Ahx-β-Amyloid (1-40) | 1802086-72-1 | Biotin-Ahx-β-Amyloid (1-40) is a biologically active peptide. |
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V78468 | Biotin-β-amyloid (1-28) (Biotin-amyloid β-protein (1-28)) | Biotin-β-amyloid (1-28) (Biotin-amyloid β-protein (1-28)) is a biotin-labeled β-Amyloid (1-28). | |
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V78469 | Biotin-β-Amyloid (1-42), human TFA (Biotin-amyloid β-peptide (1-42) (human) TFA) | Biotin-β-Amyloid (1-42), human TFA (Biotin-Amyloid β-Peptide (1-42) (human) TFA) is biotin-labeled β-Amyloid (1-42), human TFA. | |
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V78470 | Biotin-β-Amyloid (17-40) | Biotin-β-Amyloid (17-40) is an N-terminally tagged biotinylated amyloid β-Amyloid (17-40) peptide. | |
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V71398 | Biotinyl-Ahx-Amyloid β-Protein (1-42) | 1872440-40-8 | Biotinyl-Ahx-Amyloid β-Protein (1-42) is a biotinylated β-Amyloid (1-42), human (TFA). |
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V78464 | Biotinyl-Ahx-Amyloid β-Protein (1-42) (ammonium) | Biotinyl-Ahx-Amyloid β-Protein (1-42) ammonium is an N-terminal biotin-labeled Amyloid β-Protein (1-42). | |
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V78465 | Biotinyl-Amyloid β-Protein (1-42) (ammonium) | Biotinyl-Amyloid β-Protein (1-42) ammonium is a biotinylated Amyloid β-Protein (1-42). | |
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V71370 | Birtamimab (NEOD001) | 1608108-91-3 | Birtamimab (NEOD001) is an investigational monoclonal antibody (mAb) that specifically and selectively targets and clears amyloid. |
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V77153 | Chemerin-9 (149-157) (TFA) | Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1). | |
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V78803 | Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40); Citrullinated Aβ40) | Citrullinated amyloid-β (1-40) peptide (human) (Citrullinated Aβ (1-40)) is a modified form of β-Amyloid (1-40) that is citrullinated at the Arg5 site. | |
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V78804 | Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42); Citrullinated Aβ42) | Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) that is citrullinated at the Arg5 site. | |
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V71365 | Cl-NQTrp | 185351-23-9 | Cl-NQTrp significantly disrupts preformed fibrillar aggregates of tau-derived PHF6 (VQIVYK) peptide and full-length tau protein. |
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V71432 | Coumarinic acid | 495-79-4 | Coumarinic acid is a brain-penetrating inhibitor of AChE and β-amyloid. |
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V18783 | CRANAD-2 | 1193447-34-5 | CRANAD-2 is adifluoroboron-based curcumin acting as anear-infrared (NIR) Aβ plaque-specific fluorescent probe for in vivo detection of amyloid-beta deposits. |
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V71372 | Crenezumab (MABT 5102A; RG 7412) | 1095207-05-8 | Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody (mAb) that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, and may be used in AD/Alzheimer's disease study. |
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