As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2810 | FPS-ZM1 | 945714-67-0 | FPS-ZM1 is a potent and high-affinityRAGEspecific blocker with Kivalue of 25 nM. |
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V21547 | Geniposide | 24512-63-8 | Geniposide is an iridoid glycoside found in gardenia flowers; possesses diverse biological effects like antidiabetic, antioxidant, antiproliferation, and neuro-protective (neuro-protection) activities. |
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V71440 | Glp-amyloid-β (3-40) peptide (human) (AβpE3-40) | 161818-04-8 | Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a small amount of pyroglutamic acid-modified Aβ extracted from 24-month-old amyloid precursor protein transgenic mice. |
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V79396 | Glutaminyl Cyclase Inhibitor 5 | Glutaminyl Cyclase Inhibitor 5 (Compound 71) is a potent and specific inhibitor of human glutaminyl cyclase (hQC) with IC50 of 3.2 nM. | |
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V79691 | hAChE-IN-3 | hAChE-IN-3 (compounds 5c) is a potent and BBB (blood-brain barrier) permeable (penetrable) inhibitor of AChE, BuChE, MAO-B-IN-1 and BACE-1 with IC50s of 0.44, 0.08, 5.15 and 1, respectively. | |
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V79693 | hAChE-IN-5 | hAChE-IN-5 (compound 49) is a potent inhibitor of hAChE and hBuChE with IC50s of 0.17 μM and 0.17 μM, respectively. | |
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V79406 | hAChE/hBACE-1-IN-2 | hAChE/hBACE-1-IN-2 is a potent, orally bioactive, BBB (blood-brain barrier) permeable (penetrable) triple inhibitor of hAChE/hBChE/hBACE-1 with IC50s of 0.113 μM, 1.48 μM and 0.38 μM respectively. | |
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V71389 | Heishuixiecaoline A | 1469493-85-3 | Heishuixiecaoline A is a sesquiterpenoid. |
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V2021 | Hematoxylin (Haematoxylin) | 517-28-2 | Hematoxylin (also known as Hydroxybrazilin; Natural Black 1) is a natural compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology. |
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V31301 | Hoechst 34580 (HOE 34580) | 23555-00-2 | Hoechst 34580 is a marking dye from the Hoechst range. |
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V71356 | Hoechst 34580 tetrahydrochloride (HOE 34580 tetrahydrochloride) | 2310135-08-9 | Hoechst 34580 tetra HCl is a marking dye from the Hoechst range. |
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V24107 | Licochalcone B | 58749-23-8 | Licochalcone B,a naturally occuring chalcone compound isolated from the root ofGlycyrrhiza inflate, is an inhibitor of phosphorylation of NF-kappaB p65 in LPS signaling pathway. |
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V71418 | LPYFD-NH2 | 700361-48-4 | LPYFD-NH2 is a pentapeptide that can inhibit the aggregation of Aβ(1-42). |
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V80619 | LPYFD-NH2 TFA | LPYFD-NH2 TFA is a pentapeptide that can inhibit the aggregation of Aβ(1-42). | |
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V71420 | MCAAD-3 | 1625629-51-7 | MCAAD-3 is a near-infrared Aβ imaging probe with BBB (blood-brain barrier) penetration. |
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V71441 | Methyl tridecanoate | 1731-88-0 | Methyl tridecanoate moderately inhibits β-amyloid protein (β-amyloid) aggregation. |
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V71367 | OAB-14 | 2140911-49-3 | OAB-14, a Bexarotene analogue, improves AD/Alzheimer's disease-related pathology and cognitive impairment by increasing beta-amyloid clearance in APP/PS1 mice. |
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V71428 | p-HTAA | 1175142-38-7 | p-HTAA is a pentameric hydrothiopheneacetic acid. |
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V71380 | PHF6 | 329897-62-3 | PHF6 (VQIVYK) is a self-assembly sequence that initiates aggregation of full-length tau protein and maps to the third microtubule-binding repeat region of tau protein. |
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V85737 | QP5020 | 3027434-06-3 |
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