Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors.Ten distinct prostaglandin receptors on different cell types are currently known. G-protein-coupled receptors are a subclass of cell surface seven-transmembrane receptors that prostaglandins bind to. The following are the names of these receptors: FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor, EP1-4-EP1, EP2, EP3, and EP4 receptors. A class of lipid molecules known as prostaglandins, which are produced enzymatically from fatty acids and resemble hormones, play vital roles in the bodies of animals. Ten distinct prostaglandin receptors on different cell types are currently known.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73508 | Canniprene | 70677-47-3 | Canniprene is a prenylated bibenzyl unique to cannabis and is responsible for 5-lipoxygenase (5-LO) activity (IC50=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2; Effective inhibitor (antagonist) with IC50=10 μM). |
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V4963 | CAY10471 Racemate | 844639-57-2 | CAY10471 Racemate (also known as TM-30089 Racemate) is a novel, potent and highly selective prostaglandin D2 receptor CRTH2 antagonist with a Kiof 0.6 nM for hCRTH2, it is selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). |
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V74461 | CAY10580 | 64054-40-6 | CAY10580 is a potent and specific prostaglandin EP4 receptor (EP4) agonist (Ki=35 nM). |
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V18401 | CJ-042794 (CJ-042794) | 847728-01-2 | CJ-042794 (CJ-042794) is a a novel, potent, and selective prostaglandin EP(4) receptor antagonist, with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3). |
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V2991 | CP-544326 | 752187-80-7 | Taprenepag (formerly known as CP-544326) is a potent and selective agonist of EP2 (prostaglandin EP receptor 2) with IC50 of 10nM and EC50 of 2.8nM. |
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V19993 | Dinoprost Tromethamine | 38562-01-5 | Dinoprost Tromethamine (Prostaglandin F2alpha; PGF2α THAM; Prostaglandin F2α THAM) is apotent,naturally occurring andorally bioactiveprostaglandin that acts as aprostaglandin F (PGF) receptor (FP receptor)agonist withoxytocic, luteolytic, and abortifacient activities. |
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V13210 | E7046 | 1369489-71-3 | E7046 is a potent and selective antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4. |
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V74472 | EP2 receptor antagonist-1 | 848920-08-1 | EP2 receptor antagonist-1 (Compound 1) is a potent, reversible and agonist-dependent allosteric prostaglandin EP2 receptor antagonist. |
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V74462 | EP2 receptor antagonist-2 | 615273-95-5 | EP2 receptor antagonist-2 (CID891729) is an EP2 receptor antagonist. |
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V74457 | EP3 antagonist 4 | 2408297-80-1 | EP3 antagonist 4 (Compound 28) is an EP3 antagonist (inhibitor) with a Ki of 2 nM for hEP. |
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V74475 | EP4 receptor antagonist 2 | 1965316-82-8 | EP4 receptor antagonist 2 (compound 2-13) is a potent EP4 receptor agonist/activator with IC50 of 7.8 nM. |
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V74489 | EP4 receptor antagonist 3 | 1207954-34-4 | EP4 receptor antagonist 3 is a potent EP4 receptor antagonist, Example 3, derived from the patented product WO2010019796 A1. |
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V74479 | EP4-IN-1 | 2455480-28-9 | EP4-IN-1 is a potent prostaglandin EP4 receptor blocker/inhibitor. |
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V67695 | Epi-cryptoacetalide (Epi-cryptoacetalide) | 132152-57-9 | Epi-cryptoacetalide is a natural diterpenoid. |
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V20762 | Ethamsylate | 2624-44-4 | Ethamsylate (E-141; MD-141; Aglumin; Altodor; Eselin), a benzenesulfonate analogue, is an antihemorrhagic drug (haemostatic drug) which works by increasing resistance in the endothelium of capillaries and promoting platelet adhesion. |
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V2855 | Evatanepag (CP-533536) | 223488-57-1 | Evatanepag (formerly known as CP-533536; CP-533536 free acid) is a novel, potent and selective agonist of EP2 receptor prostaglandin E2 (PGE2). |
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V3987 | FEVIPIPRANT | 872365-14-5 | Fevipiprant (formerly known as NVP-QAW039 or QAW039) is a novel, selective, potent, oral active and reversible competitive CRTh2 (chemoattractant receptor-homologous molecules expressed on T-helper type 2) antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood. |
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V11725 | Genz-123346 | 491833-30-8 | Genz-123346 is a novel, potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. |
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V3983 | GRAPIPRANT | 415903-37-6 | Grapiprant (formerly known as CJ-023,423, RQ-00000007, or AAT-007) is a selective and potent EP4 receptor antagonist. |
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V4931 | GW627368 | 439288-66-1 | GW627368 (also known as GW-627368; GW-627368X) is a novel, orally bioavailable, potent and selective competitive antagonist of prostanoid EP4 receptor with anticancer activity. |
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