Opioid ligands are a class of G protein-coupled receptors known as opioid receptors. Dynorphins, enkephalins, endorphins, endomorphins, and nociceptin are examples of endogenous opioids. There are many opioid receptors in the brain, as well as in the spinal cord and digestive system. The body has molecules or sites called opioid receptors that are triggered by opioid substances. Opioid receptors prevent impulses from traveling along excitatory pathways in the human body.The serotonin, catecholamine, and substance P pathways are some of these pathways, and they are all thought to play a role in pain perception and feelings of wellbeing. Mu, delta, and kappa receptors are additional subclassifications of opioid receptors. While each class has its own unique way of acting, they all have some fundamental things in common. The potassium pump mechanism, which is present on the plasma membrane of most cells, powers them all.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69923 | [DAla2] Dynorphin A (1-13), amide (porcine) | 79985-43-6 | [DAla2] Dynorphin A (1-13), amide (porcine) is a bioactive peptide. |
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V69927 | [DPen2, Pen5] Enkephalin | 88373-72-2 | [DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin . |
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V69949 | [DPro10] Dynorphin A (1-11), porcine | 94596-26-6 | [DPro10] Dynorphin A (1-11), porcine is an N-alkylated analogue and a potent kappa-opioid receptor agonist/activator with a Ki of 0.13 nM. |
|
V77476 | [DPro10] Dynorphin A (1-11), porcine hydrochloride | [DPro10] Dynorphin A (1-11), porcine HCl is an N-alkylated analogue and a potent kappa-opioid receptor agonist/activator with a Ki of 0.13 nM. | |
|
V69881 | [Met5]-Enkephalin, amide TFA (5-Methionine-enkephalin amide TFA) | 2918768-28-0 | [Met5]-Enkephalin, amide TFA is a delta and zeta opioid receptor agonist (activator). |
|
V69965 | [Nphe1]Nociceptin(1-13)NH2 | 267234-08-2 | [Nphe1]Nociceptin(1-13) NH2 is a Nociceptin/orphanin FQ (NC) endogenous ligand and a selective and competitive ociceptin receptor antagonist (inhibitor) without agonist activity. |
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V77483 | [Nphe1]Nociceptin(1-13)NH2 TFA | [Nphe1]Nociceptin(1-13) NH2 TFA is an endogenous ligand of Nociceptin/orphanin FQ (NC) and is a selective and competitive ociceptin receptor antagonist (inhibitor) without agonist activity. | |
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V69954 | Ac-RYYRIK-NH2 | 200959-48-4 | Ac-RYYRIK-NH2 is a potent ORL1 partial agonist that works as an endogenous ligand of ORL1 in CHO cells (Kd=1.5 nM). |
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V77780 | Ac-RYYRIK-NH2 TFA | Ac-RYYRIK-NH2 TFA is a potent ORL1 partial agonist that works as an endogenous ligand of ORL1 in CHO cells (Kd=1.5 nM). | |
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V69952 | Ac-RYYRWK-NH2 | 200959-47-3 | Ac-RYYRWK-NH2 is a potent and specific nociceptin receptor (NOP) partial agonist. |
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V69908 | Ac-RYYRWK-NH2 TFA | 408305-09-9 | Ac-RYYRWK-NH2 TFA is a potent and specific nociceptin receptor (NOP) partial agonist. |
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V1276 | ADL5859 HCl | 850173-95-4 | ADL5859 HCl (ADL 5859; ADL-5859),the hydrochloride salt of ADL5859, is a potent, orally bioavailable δ-opioid receptor agonist with important biological activity. |
|
V3722 | Alvimopan | 156053-89-3 | Alvimopan (also known as ADL 8-2698; LY 246736; HSDB-7704) is a novel peripheral micro opioid antagonist in clinical development for the management of post-operative ileus and opioid-induced bowel dysfunction. |
|
V3724 | Alvimopan dihydrate | 170098-38-1 | Alvimopan (also known as ADL 8-2698; LY 246736; HSDB-7704) is a novel peripheral micro opioid antagonist in clinical development for the management of post-operative ileus and opioid-induced bowel dysfunction. |
|
V3723 | Alvimopan monohydrate | 1383577-62-5 | Alvimopan (also known as ADL 8-2698; LY 246736; HSDB-7704) is a novel peripheral micro opioid antagonist in clinical development for the management of post-operative ileus and opioid-induced bowel dysfunction. |
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V69937 | Anrikefon acetate (HSK21542 acetate) | 2584931-05-3 | Anrikefon (HSK21542) acetate is a kappa opioid receptor agonist (activator) with pain-relief effects. |
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V2073 | AR-M 1000390 HCl | 209808-47-9 | AR-M 1000390 hydrochloride (the hydrochloric acid of ARM-390; AR-M1000390) is a potent, highly selective agonist of δ opioid receptor that can induce insulin depletion in the rat and RINm5F cells. |
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V11693 | Asimadoline | 153205-46-0 | Asimadoline (EMD-61753) is an orally bioactive, selective, peripherally active kappa-opioid agonist with IC50s of 5.6 nM and 1.2 nM for guinea pig and human recombinant kappa-opioid, respectively. |
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V69926 | AT-121 | 2099681-31-7 | AT-121 is a bifunctional nociception and mu opioid receptor agonist/activator with Kis of 3.67 and 16.49 nM respectively. |
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V69930 | AT-121 hydrochloride | 2099681-71-5 | AT-121 HCl is a bifunctional nociception and mu opioid receptor agonist/activator with Kis of 3.67 and 16.49 nM respectively. |
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