|
V4867
|
LY-341495 |
201943-63-7 |
LY 341495 is a novel, potent and selective orthosteric antagonist of the metabotropic glutamate receptors (mGluR) with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively. |
|
V70602
|
LY3020371 |
1377615-75-2 |
LY3020371 is a potent and specific glutamate receptor (mGluR2/3) antagonist (inhibitor) with Kis of 5.26 and 2.50 nM for hmGluR2 and hmGluR3, respectively. |
|
V70604
|
LY3027788 |
1377615-76-3 |
LY3027788 is a diester analog of LY3020371, an antagonist of mGlu2/3 receptor, and a potent orally bioactive prodrug of LY3020371. |
|
V70605
|
LY3027788 hydrochloride |
1377615-55-8 |
LY3027788 HCl is a diester analog of LY3020371, an antagonist of mGlu2/3 receptor, and a potent orally bioactive prodrug of LY3020371. |
|
V70593
|
LY367385 hydrochloride |
2829282-00-8 |
LY367385 HCl is a highly efficient and selective mGluR1a antagonist, with IC50 of 8.8 μM for inhibiting quinquinoline-induced hydrolysis of phosphoinositide, while the IC50 for mGlu5a is greater than 100 μM. |
|
V14550
|
LY487379 HCl |
353229-59-1 |
LY-487379 is a novel, potent and selective PAM (positive allosteric modulator) for the metabotropic glutamate receptor group II subtype mGluR2. |
|
V70624
|
MCPG sodium |
1303994-09-3 |
MCPG is a carboxyphenylglycine. |
|
V4662
|
MFZ 10-7 |
1224431-15-5 |
MFZ 10-7 is a selective mGluR5 negative allosteric modulator (NAM) with Ki of 0.67 nM for rat mGluR5. |
|
V70600
|
mGluR2 antagonist 1 |
1432728-49-8 |
mGluR2 antagonist 1 is an orally bioactive, BBB (blood-brain barrier) permeable/penetrable, selective negative allosteric modulator (NAM) of mGluR2 (IC50 is 9 nM). |
|
V70623
|
mGluR3 modulator-1 |
374548-18-2 |
mGluR3 modulator-1 (compound 3) is a modulator of mGluR3 with EC50 of 1-10 μM measured in the HEK293T-mGluR-Gqi5 calcium motility assay. |
|
V70618
|
mGluR5 antagonist-1 |
2761424-76-2 |
mGluR5antagonist-1 is a high-affinity mGluR5 antagonist (inhibitor) with IC50 of 11.5 nM. |
|
V70622
|
mGluR5 modulator 1 |
1261171-52-1 |
mGluR5 modulator 1 is a PAM (positive allosteric modulator) of mGluR5. |
|
V70601
|
MGS0274 |
1501974-69-1 |
MGS0274 is a lipophilic precursor of the mGlu2 and mGlu3 receptor agonist MGS0008, which improves oral bioavailability (F). |
|
V70631
|
MK-8768 |
1432729-22-0 |
MK-8768 is an orally bioactive, BBB (blood-brain barrier) permeable/penetrable, selective mGluR2 negative allosteric modulator (NAM) (IC50 of 9 nM). |
|
V2285
|
ML 254 |
1428630-86-7 |
ML254 is a potent mGlu5 enhancer with EC50 and pEC50 of 9.3 nM for mouse mGlu5. |
|
V76761
|
ML353 |
|
ML353 is a selective ligand for the mGlu5 silent allosteric modulator (SAM) with a Ki of 18.2 nM. |
|
V70613
|
MMPIP hydrochloride |
1215566-78-1 |
MMPIP HCl is an allosteric and selective metabotropic glutamate receptor 7 (mGluR7) antagonist (KB range 24-30 nM). |
|
V3421
|
MPEP hydrochloride |
219911-35-0 |
MPEP hydrochloride is a highly potent, selective, and non-competitive antagonist of mGlu5 receptor with IC50 of 36 nM, it exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. |
|
V70611
|
MTEP |
329205-68-7 |
MTEP is a potent, noncompetitive and selective mGluR5 antagonist. |
|
V70621
|
NPEC-caged-LY379268 |
1315379-62-4 |
NPEC-caged-LY379268 is a Group II mGluR agonist. |