| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V12032 | PHCCC | 179068-02-1 | PHCCC is a potent PAM (positive allosteric modulator) of mGluR4 and a Group I metabotropic glutamate receptor antagonist with IC50 of ~ 3 μM. |
|
V3342 | Ro 67-7476 | 298690-60-5 | Ro 67-7476 is a novel and selective positive allosteric modulator of mGlu1 receptors. |
|
V70616 | trans-ACPD (Trans-(±)-ACP) | 67684-64-4 | trans-ACPD is a metabotropic receptor agonist (activator) that promotes calcium ion activity and generates inward current. |
|
V70596 | UPF-523 (AIDA) | 168560-79-0 | UPF-523 (AIDA) is a rigid (carboxyphenyl) glycine analogue and a potent and specific antagonist of group I metabotropic glutamate receptor (mGlu1a) with IC50 of 214 μM. |
|
V27895 | UV-0155041 | 1093757-42-6 | UV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). |
|
V28110 | VU-1545 | 890764-63-3 | VU-1545 (VU1545) is a novel and potent modulator of metabotropic glutamate receptor 5, or positive allosteric modulator (mGluR5 PAM) (Ki =156 nM and EC50 = 9.6 nM). |
|
V70598 | VU-29 | 890764-36-0 | VU-29 is a PAM (positive allosteric modulator) of the metabotropic glutamate 5 (mGlu5) receptor (EC50=9 nM, Ki=244 nM for rmGluR5). |
|
V70638 | VU0029251 | 330819-85-7 | VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM). |
|
V70609 | VU0155041 sodium | 1259372-69-4 | VU0155041 sodium is a specific mGluR4 mixed allosteric agonist/PAM (positive allosteric modulator) with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. |
|
V70610 | VU0360172 hydrochloride | 1309976-62-2 | VU0360172 HCl is a potent and specific PAM (positive allosteric modulator) of the mGlu5 receptor with EC50 of 16 nM and a Ki of 195 nM. |
|
V70607 | VU0364770 hydrochloride | 1414842-70-8 | VU0364770 HCl is a potent and specific mGlu4 PAM (positive allosteric modulator). |
|
V32195 | VU0650786 | 1809085-30-0 | VU0650786 is a novel, potent, selective and CNS permeable negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. |
|
V70627 | VU6004909 | 1860797-76-7 | VU6004909 is a PAM (positive allosteric modulator) of mGlu5 receptor (pEC50= 7.59). |
|
V31649 | VU6005649 | 2137047-43-7 | VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. |
|
V70606 | VU6010572 | 2126784-39-0 | VU6010572 is a potent and specific mGlu3 NAM (negative allosteric modulator) with IC50 of 245 nM. |
|
V3321 | VU6012962 | 2313526-86-0 | VU6012962 is a novel, potent, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu7) negative allosteric modulator (NAM) with an IC50 of 347 nM. |
|
V70597 | YM-298198 hydrochloride | 1216398-09-2 | YM-298198 HCl is a high-affinity, selective, orally bioactive, noncompetitive mGluR1 antagonist. |
|
V70628 | Z-Cyclopentyl-AP4 | 103439-17-4 | Z-Cyclopentyl-AP4 is a kainate-type glutamate receptor agonist (activator) (orthosteric agonist). |
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