| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| Targets |
mGlu7
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|---|---|
| ln Vitro |
In Chinese hamster ovary (CHO) cells coexpressing rat mGluR7 with Gα15 (IC50=26 nM), MMPIP reduces the intracellular Ca2+ mobilization elicited by L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM) [1]. MMPIP blocks L-AP4-induced suppression of forskolin-stimulated cAMP buildup (IC50 220 nM) in CHO cells expressing rat mGluR7[1]. Additionally, MMPIP counteracts the suppression of cAMP buildup mediated by L-AP4 in CHO-human mGluR7/Gα15, with an IC50 of 610 nM[1].
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| ln Vivo |
MMPIP (10 mg/kg) significantly increases the prepulse-induced suppression of the auditory startle response (up to 137% of control) while attenuating the intensity of the acoustic startle reaction[2]. By increasing decision accuracy, MMPIP (10 mg/kg) mitigates the cognitive deficits caused by MK -801 (0.1 mg/kg)[2]. After being injected intraperitoneally (10 mg/kg), zamifenacin shows brief elimination half-lives (plasma 1.16 h, brain 1.75 h) in mice[ 2].
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| References |
[1]. Gentaroh Suzuki, et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther. 2007 Oct;323(1):147-56.
[2]. Paulina Cieślik, et al. Negative Allosteric Modulators of mGlu 7 Receptor as Putative Antipsychotic Drugs. Front Mol Neurosci. 2018 Sep 20;11:316. |
| Molecular Formula |
C19H16CLN3O3
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|---|---|
| Molecular Weight |
369.80
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| CAS # |
1215566-78-1
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| Related CAS # |
MMPIP;479077-02-6
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| SMILES |
CC1=NC=CC=C1OC1=CC=C(NC(N2CCC3=CC(=C(C=C23)Cl)C)=O)C=N1
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 10 mg/mL (27.04 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1 mg/mL (2.70 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7042 mL | 13.5208 mL | 27.0416 mL | |
| 5 mM | 0.5408 mL | 2.7042 mL | 5.4083 mL | |
| 10 mM | 0.2704 mL | 1.3521 mL | 2.7042 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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