| Size | Price | Stock | Qty |
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Purity: ≥98%
Idazoxan HCl (RX781094A; RX-781094 hydrochloride) is a potent and selective α2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has not been brought to market as an antidepressant for the treatment of schizophrenia, although it has been studied for this purpose.
| Targets |
α adrenergic receptor
|
|---|---|
| ln Vivo |
Idazoxan HCl (RX781094A; RX-781094 hydrochloride) is a potent and selective α2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has not been brought to market as an antidepressant for the treatment of schizophrenia, although it has been studied for this purpose.
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| Animal Protocol |
Male CD-COBS rats injected with 1 mg/kg haloperidol
0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0 mg/kg Subcutaneous injection; for 1 hour |
| References |
|
| Molecular Formula |
C11H13CLN2O2
|
|---|---|
| Molecular Weight |
240.686
|
| Exact Mass |
240.07
|
| Elemental Analysis |
C, 54.89; H, 5.44; Cl, 14.73; N, 11.64; O, 13.29
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| CAS # |
79944-56-2
|
| Related CAS # |
79944-56-2 (HCl); 79944-58-4
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| Appearance |
Solid powder
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| SMILES |
C1CN=C(N1)C2COC3=CC=CC=C3O2.Cl
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| InChi Key |
MYUBYOVCLMEAOH-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
|
| Chemical Name |
2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole;hydrochloride
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| Synonyms |
RX-781094A; RX781094A; RX781094; RX 781094A; RX 781094; Idazoxan HCl; RX-781094; Idazoxan hydrochloride
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~125 mg/mL (~519.3 mM)
H2O: ~100 mg/mL (~415.5 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (8.64 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (8.64 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (8.64 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 50 mg/mL (207.74 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1547 mL | 20.7736 mL | 41.5472 mL | |
| 5 mM | 0.8309 mL | 4.1547 mL | 8.3094 mL | |
| 10 mM | 0.4155 mL | 2.0774 mL | 4.1547 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT05727189 | Recruiting | Drug: TR-01-XRS Drug: TR-01-XR Drug: TR-01-IR |
Healthy | Terran Biosciences Australia Pty Ltd |
February 14, 2023 | Phase 1 |
Products are for research use only; We do not sell to patients
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