5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0968 | RS-127445 | 199864-87-4 | RS-127445 (RS 127445; RS127445) is a novel, potent, selective, and orally bioavailable 5-HT2B receptor antagonist with important biological activity. |
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V71137 | RU 24969 hemisuccinate | 66611-27-6 | RU 24969 hemisuccinate is a preferential 5-HT1B agonist/activator with a Ki of 0.38 nM. |
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V102082 | S 32212 hydrochloride | 847871-78-7 | 32212 hydrochloride is an inverse agonist at the serotonin (5-HT) receptor subtypes 5-HT2CINI and 5-HT2CVSV (Kis 6.6 and 8.9 nM, respectively). |
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V102452 | S(-)-8-OH-DPAT hydrobromide | 78095-20-2 | S(-)-8-OH-DPAT (S(-)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is the enantiomer of 8-OH-DPAT hydrobromide. |
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V102167 | S-14506 | 135722-25-7 | S-14506 hydrochloride is a potent 5-HT1A agonist. |
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V103292 | SAM-315 | 744218-85-7 | SAM-315 (WAY-255315) is a potent 5-HT-6 antagonist with Ki and IC50 of 1.1 nM and 4.6 nM, respectively. |
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V4607 | SB 242084 HCl | 1049747-87-6 | SB-242084 HCl, the hydrochloride salt ofSB 242084, is a novel, potent and selective 5-HT2C receptor antagonist with pKi of 9.0 and with 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. |
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V101120 | SB 242084 monohydrochloride | 1260505-34-7 | SB 242084 hydrochloride is a selective, competitive and high affinity (pKi=9.0) 5-HT2C receptor antagonist (can penetrate the blood-brain barrier). |
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V71123 | SB 243213 | 200940-22-3 | SB 243213 is an orally bioactive, selective, high-affinity 5-HT2C receptor antagonist (inhibitor) with pKi of 9.37 and a pKb of 9.8 for the human 5-HT2C receptor. |
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V0984 | SB 271046 (SB-271046A) | 209481-20-9 | SB271046 (SB 271046; SB-271046; SB-271046A; SB271046A) is a novel, potent, selective and orally bioactive 5-HT6 receptor antagonist with important biological activity. |
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V0980 | SB 271046 HCl (SB-271046A) | 209481-24-3 | SB271046 HCl (SB 271046; SB-271046), the hydrochloride salt of SB 271046, is a novel, potent, selective and orally bioactive 5-HT6 receptor antagonist with potential anticonvulsant activity. |
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V71150 | SB-200646A HCl | 143797-62-0 | SB-200646A HCl salt is the first antagonist selective for 5-HT2B/2C over 5-HT2A, with pKis of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A respectively. |
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V86151 | SB 206553 | 158942-04-2 | SB-206553 is a 5-HT2C inverse agonist. |
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V87764 | SB-258585 | 209480-63-7 | SB-258585 is a selective, high-affinity ligand for the 5-HT6 receptor with a pKi value of 8.53. |
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V4617 | SB-399885 HCl | 402713-81-9 | SB 399885 hydrochloride is a novel, potent, brain penetrant, and orally bioactive 5-HT6 receptor antagonist. |
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V2619 | SB269970 (SB-269970A) | 201038-74-6 | SB269970 (SB-269970A)is a novel and potent 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors. |
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V1019 | SB269970 HCl (SB-269970A) | 261901-57-9 | SB269970 HCl (SB 269970; GR125743; GR-125743; SB-269970), the hydrochloride salt form of SB-269970, is a novel and potent 5-HT7 receptor antagonist withantianxiety-like effects. |
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V71169 | SB399885 | 402713-80-8 | SB399885 is a specific, BBB (blood-brain barrier) permeable (penetrable) and orally bioactive 5-HT6 receptor antagonist (inhibitor) with pKis of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. |
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V101915 | SDZ 205-557 | 137196-67-9 | SDZ 205-557 is a selective 5-HT4 receptor antagonist. |
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V96773 | Seganserin | 87729-89-3 | Seganserin is an orally active 5-HT receptor antagonist with a plasma half-life of 26.1 ± 12.9 (SD) hours. |
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