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    ARQ 621
    ARQ 621

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1631
    CAS #: 1095253-39-6Purity ≥98%

    Description: ARQ 621 is a potent, allosteric, and selective Eg5 mitotic motor protein inhibitor. Eg5 is essential for the dynamic organization of the mitotic spindle. Over-expression of Eg5 leads to genomic instability and tumor formation. Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target. Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies. 

    References: Rosen L, et al. Annual Meeting of ASCO: abstract 3076

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    Molecular Weight (MW)552.43
    FormulaC28H24Cl2FN5O2
    CAS No.1095253-39-6
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (181.0 mM)
    Water:<1 mg/mL
    Ethanol: 100 mg/mL (181.0 mM)
    Other info

    Chemical Name: (R)-N-(3-aminopropyl)-3-chloro-N-(1-(7-chloro-4-oxo-3-(phenylamino)-3,4-dihydroquinazolin-2-yl)but-3-yn-1-yl)-2-fluorobenzamide

    InChi Key: UPJSUQWHUVLLNW-XMMPIXPASA-N

    InChi Code: InChI=1S/C28H24Cl2FN5O2/c1-2-8-24(35(16-7-15-32)27(37)21-11-6-12-22(30)25(21)31)26-33-23-17-18(29)13-14-20(23)28(38)36(26)34-19-9-4-3-5-10-19/h1,3-6,9-14,17,24,34H,7-8,15-16,32H2/t24-/m1/s1

    SMILES Code: O=C(N(CCCN)[[email protected]@H](C(N1NC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC#C)C4=CC=CC(Cl)=C4F           

    SynonymsARQ621; ARQ 621; ARQ-621


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    In Vitro

    In vitro activity: ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells.

    In VivoARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs.
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    References

    Rosen L, et al. Annual Meeting of ASCO: abstract 3076.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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