| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
IC50: 1.3 μM (Drp1)[1]
|
|---|---|
| ln Vitro |
MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1]. MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1].
|
| References |
| Molecular Formula |
C26H27N5OS
|
|---|---|
| Molecular Weight |
457.59
|
| CAS # |
2247732-89-2
|
| SMILES |
S1C=C(CN2C=C(C)C=C2C(NC2C=CC(C3C=NC=CC=3)=CC=2)=O)N=C1N1CCCCC1
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1854 mL | 10.9268 mL | 21.8536 mL | |
| 5 mM | 0.4371 mL | 2.1854 mL | 4.3707 mL | |
| 10 mM | 0.2185 mL | 1.0927 mL | 2.1854 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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