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    Dyngo-4a
    Dyngo-4a

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1592
    CAS #: 1256493-34-1Purity ≥98%

    Description: Dyngo-4a is a potent and novel dynamin inhibitor with IC50 values of 0.38 μM, 1.1 μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. Dyngo-4a (100 μM) caused a reduction in β-catenin levels in human colon carcinoma RKO cells. In addition, Dyngo-4a prevented the uptake of BoNT/A-Hc and blocked BoNT/A-induced SNAP25 cleavage in cultured hippocampal neurons.

    References: Traffic. 2013 Dec;14(12):1272-89; J Cell Sci. 2014 Nov 15;127(Pt 22):4918-26. 

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    • 香港大学
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    Molecular Weight (MW)338.31
    FormulaC18H14N2O5
    CAS No.1256493-34-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 67 mg/mL (198.0 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide

    InChi Key: UAXHPUSKEWEOAP-DJKKODMXSA-N

    InChi Code: InChI=1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+

    SMILES Code: O=C(C1=C(O)C=C2C=CC=CC2=C1)N/N=C/C3=CC(O)=C(O)C=C3O           

    Synonyms

    Dyngo-4a; Dyngo 4a; Dyngo4a; Hydroxy Dynasore


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    In Vitro

    In vitro activity: Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC₅₀ of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin.


    Cell Assay: Dyngo-4a (100 μM) caused a reduction in β-catenin levels in human colon carcinoma RKO cells. In addition, Dyngo-4a prevented the uptake of BoNT/A-Hc and blocked BoNT/A-induced SNAP25 cleavage in cultured hippocampal neurons. Dyngo-4a is potent, reversible endocytosis inhibitor in non-neuronal cells. Dyngo-4a inhibited synaptic vesicle endocytosis (SVE) in synaptosomes and neurons with an IC50 value of 26.8 μM.

    In VivoDynamin is a potential therapeutic target for counteracting botulism. Dyngo-4a (30 mg/kg, intraperitoneal injection) treatment suppressed BoNT/A-induced muscle paralysis at the rat hemidiaphragm and significantly delayed the onset of botulism in an in vivo murine model.
    Animal modelMurine
    Formulation & Dosage30 mg/kg, intraperitoneal injection
    References

    Traffic. 2013 Dec;14(12):1272-89; J Cell Sci. 2014 Nov 15;127(Pt 22):4918-26. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Dyngo-4a

    Dyngo compounds are potent, reversible inhibitors of endocytosis in non‐neuronal cells. Traffic. 2013 Dec;14(12):1272-89.
     

    Dyngo-4a

    Dyngo compound 4a inhibits SVE in synaptosomes and neurons. Traffic. 2013 Dec;14(12):1272-89.
     

    Dyngo-4a

    Dyngo compound 4a inhibits both CME and ADBE. Traffic. 2013 Dec;14(12):1272-89.


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