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    Veliparib dihydrochloride
    Veliparib dihydrochloride

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4417
    CAS #: 912445-05-7Purity ≥98%

    Description: Veliparib dihydrochloride (also known as ABT888 dihydrochloride; ABT-888 dihydrochloride) is a novel and potent inhibitor of PARP1 and PARP2 [Poly (ADP-Ribose) Polymerase] with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It has chemosensitizing and antitumor activities, and is inactive against SIRT2. ABT-888 has demonstrated excellent in vivo efficacy in a broad spectrum of preclinical tumor models in combination with a variety of cytotoxic agents. ABT-888 is also active on microsatellite instability (MSI) cell lines harboring mutations in both MRE11 and RAD50 genes compared to microsatellite stable (MSS) cell lines (wild-type for both genes). ABT-888 has no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents.

    References: Clin Cancer Res. 2007 May 1;13(9):2728-37; Clin Cancer Res. 2007 May 15;13(10):3033-42; Clin Cancer Res. 2008 Nov 1; 14(21): 6877–6885.

    Related CAS:  912444-00-9 (free base)

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    • 香港大学
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    Molecular Weight (MW)317.21
    FormulaC13H18Cl2N4O 
    CAS No. 912445-05-7 (Veliparib dihydrochloride)
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: > 3 mg/mL  
    Water: > 50 mg/mL  
    Ethanol: N/A
    Other InfoChemical Name: 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride
    InChi Key: DSBSVDCHFMEYBX-FFXKMJQXSA-N
    InChi Code: InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1
    SMILES Code: O=C(C1=C2C(N=C([[email protected]]3(C)NCCC3)N2)=CC=C1)N.[H]Cl.[H]Cl
    SynonymsNSC 737664 dihydrochloride; NSC737664; NSC-737664 dihydrochloride; ABT888; ABT-888; ABT 888


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