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Ras

Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. Ras is the representative member of the Ras superfamily, a group of proteins that all share a common 3D structure and control a variety of cell behaviors. Incoming signals that activate Ras then activate other proteins, which in turn activate genes necessary for cell growth, differentiation, and survival. Ras proteins that are permanently activated can therefore be produced as a result of ras gene mutations.Even in the absence of incoming signals, this may result in unintended and excessive signaling within the cell. Overactive Ras signaling can ultimately result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the 3 Ras genes (HRAS, KRAS, and NRAS), and Ras inhibitors are being researched as a potential treatment for cancer and other conditions characterized by Ras overexpression.

Ras related products

Structure Cat No. Product Name CAS No. Product Description
V51444 PROTAC KRAS G12C degrader-2 2378257-72-6 PROTAC KRAS G12C degrader-2 is a K-Ras protein hydrolysis modulator.
V51460 PROTAC SOS1 degrader-1 2913185-35-8 PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM.
V51478 PROTAC SOS1 degrader-3 PROTAC SOS1 degrader-3 is a potent degrader of PROTAC SOS1.
V76568 Rac1 Inhibitor W56 TFA Rac1 Inhibitor W56 TFA is residues 45-60 in Rac1.
V13613 Ras-IN-3144 1835283-94-7 Ras-IN-3144 is a novel and potent pan-RAS inhibitor which disrupts the interaction of Ras proteins and their effectors, also inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts.
V50932 RM-018 2641993-55-5 RM-018 is a novel tricomplex KRASG12C active-state inhibitor that has different functional properties.
V50901 RMC-0331 2488788-52-7 RMC-0331 is a novel and orally active inhibitor of SOS1.
V51194 RMC-6236 2765081-21-6 RAS-IN-2 (Compound A122) is a potent RAS(ON)MULTI inhibitor that may be utilized in cancer-related research.
V51060 RMC-6291 RMC-6291 is a covalent and oral inhibitor of KRASG12C(ON).
V51471 RMC-6291 2641998-63-0 RMC-6291 is a covalent and oral inhibitor of KRASG12C(ON).
V51455 SAH-SOS1A 1652561-87-9 SAH-SOS1A is an inhibitor of the SOS1/KRAS protein interaction based on peptides.
V51437 Setidegrasib 2821793-99-9 KRAS G12D inhibitor 17 is a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound that causes the KRAS protein with the G12D mutation to degrade.
V51459 SOS1-IN-14 2793405-20-4 SOS1-IN-14 is a novel, selective, and orally active inhibitor of SOS1 with an IC50 value of 3.9 nM.
V51468 SOS1-IN-15 2793404-47-2 SOS1-IN-15 is a novel, potent and orally bioactive SOS1 inhibitor with an IC50 of 5 nM.
V51470 SOS1-IN-4 2738392-83-9 SOS1-IN-4 is a potent SOS1 inhibitor (antagonist) with IC50 of 56 nM for the KRAS-C12C/SOS1 interaction (WO2021228028 A1, example 65).
V51453 SOS1-IN-5 2716956-47-5 SOS1-IN-5 is a novel SOS1 inhibitor.
V51445 SOS1/KRAS-IN-1 2836330-34-6 SOS1/KRAS-IN-1 is a selective and novel SOS1/KRAS inhibitor that can be applied to the study of illnesses that are mediated by SOS1/KRAS.
V4841 Sotorasib (AMG-510) racemate 2252403-56-6 Sotorasib racemate (AMG-510; AMG510), the racemic mixture of AMG-510, is a novel, potent and covalent inhibitor of KRAS G12C.
V78326 Sotorasib-d7 (Sotorasib-d7; AMG-510-d7) Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled version of Sotorasib.
V51456 Spiclomazine (Clospirazine) 24527-27-3 Spiclomazine (Clospirazine) is a novel, selective mutant KRAS(G12C) inhibitor that inhibits pancreatic cancer caused by mutant KRAS in a selective manner.
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