Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. Ras is the representative member of the Ras superfamily, a group of proteins that all share a common 3D structure and control a variety of cell behaviors. Incoming signals that activate Ras then activate other proteins, which in turn activate genes necessary for cell growth, differentiation, and survival. Ras proteins that are permanently activated can therefore be produced as a result of ras gene mutations.Even in the absence of incoming signals, this may result in unintended and excessive signaling within the cell. Overactive Ras signaling can ultimately result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the 3 Ras genes (HRAS, KRAS, and NRAS), and Ras inhibitors are being researched as a potential treatment for cancer and other conditions characterized by Ras overexpression.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51416 | Garsorasib (D-1553) | 2559761-14-5 | Garsorasib is a novel KRAS G12C inhibitor with an IC50 of 10 nM. |
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V78825 | GGTI-286 TFA | GGTI-286 TFA is a potent cell-permeable (penetrable) GGTase I inhibitor (IC50 is 2 μM). | |
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V80400 | ISIS 2503 sodium | ISIS-2503 sodium is an antisense oligonucleotide that can inhibit Ha-Ras expression. | |
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V51442 | K-Ras G12C-IN-4 | 2376328-55-9 | K-Ras G12C-IN-4, compound 1, is a potent covalent/irreversible inhibitor of KRASG12C. |
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V51454 | KRA-533 | 10161-87-2 | KRA-533 is a selective KRAS agonist. |
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V51441 | KRAS G12C inhibitor 14 | 2349393-95-7 | KRAS G12C inhibitor 14 is a novel inhibitor of KRAS G12C that has an IC50 of 18 nM. |
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V51427 | KRAS G12C inhibitor 18 | 2649788-45-2 | KRAS G12C inhibitor 18 is an orally bioavailable KRAS G12C inhibitor. |
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V51202 | KRAS G12C inhibitor 19 | 2649788-46-3 | KRAS G12C inhibitor 19 is a novel and covalent KRAS G12C inhibitor. |
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V51438 | KRAS G12C inhibitor 20 | 2640858-10-0 | KRAS G12C inhibitor 20 is an inhibitor (blocker/antagonist) of KRAS G12C. |
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V51439 | KRAS G12C inhibitor 21 | 2737269-61-1 | KRAS G12C inhibitor 21 is an inhibitor (blocker/antagonist) of KRAS G12C. |
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V51440 | KRAS G12C inhibitor 22 | 2736599-72-5 | KRAS G12C inhibitor 22 is an inhibitor (blocker/antagonist) of KRAS G12C. |
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V51433 | KRAS G12C inhibitor 23 | 2735721-00-1 | KRAS G12C inhibitor 23 is a novel inhibitor of KRAS G12C. |
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V51423 | KRAS G12C inhibitor 24 | 2735742-75-1 | KRAS G12C inhibitor 24 is a novel KRAS G12C inhibitor. |
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V51430 | KRAS G12C inhibitor 25 | 2734060-73-0 | KRAS G12C inhibitor 25 is a KRAS G12C inhibitor. |
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V51424 | KRAS G12C inhibitor 42 | 2454488-02-7 | KRAS G12C inhibitor 42 is a novel and selective KRAS G12C inhibitor. |
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V51426 | KRAS G12C inhibitor 56 | 2749963-77-5 | KRAS G12C inhibitor 56 is a novel inhibitor of SOS1 with a 1.6 nM IC50. |
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V51429 | KRAS G12C inhibitor 57 | 2821863-70-9 | KRAS G12C inhibitor 57 is a novel, selective, and oral active inhibitor of KRAS G12C that has an IC50 of 0.21 μM in the KRAS G12C/SOS1 binding assay. KRAS G12C inhibitor 57 induces cancer cell apoptosis. |
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V51435 | KRAS G12C inhibitor 58 | 2915599-52-7 | KRAS G12C inhibitor 58 is an inhibitor (blocker/antagonist) of KRAS G12C and may be utilized in cancer-related research. |
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V80515 | KRAS G12C inhibitor 60 | KRAS G12C inhibitor 60 (compound 23) is a Kras-G12C inhibitor. | |
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V51432 | KRAS G12D inhibitor 1 | 2621928-43-4 | KRAS G12D inhibitor 1 (example 243) is a novel inhibitor of KRAS G12D that has an IC50 of 0.8 nM for ERK phosphorylation caused by KRAS G12D. |
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