Ras

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. Ras is the representative member of the Ras superfamily, a group of proteins that all share a common 3D structure and control a variety of cell behaviors. Incoming signals that activate Ras then activate other proteins, which in turn activate genes necessary for cell growth, differentiation, and survival. Ras proteins that are permanently activated can therefore be produced as a result of ras gene mutations.Even in the absence of incoming signals, this may result in unintended and excessive signaling within the cell. Overactive Ras signaling can ultimately result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the 3 Ras genes (HRAS, KRAS, and NRAS), and Ras inhibitors are being researched as a potential treatment for cancer and other conditions characterized by Ras overexpression.

Ras related products

Cat No.	Product Name	CAS No.	Product Description
V51428	KRAS G12D inhibitor 16	2648221-12-7	KRAS G12D inhibitor 16 is a novel KRAS G12D inhibitor.
V51434	KRAS G12D inhibitor 5	2621928-53-6	KRAS G12D inhibitor 5 is a potential KRAS G12D inhibitor studied in pancreatic cancer.
V51422	KRAS G12D inhibitor 6	2648552-32-1	KRAS G12D inhibitor 6 is a potent inhibitor of KRAS G12D (information is from patent WO2021108683A1, compound 112).
V51421	KRAS G12D inhibitor 7	2648552-34-3	KRAS G12D inhibitor 7 is a potent inhibitor of KRAS G12D (information is from patent WO2021108683, compound 114).
V51436	KRAS G12D modulator-1	2883034-05-5	KRAS G12D modulator-1 is a novel KRAS G12D modulator that has IC50 values for p ERK-AGS, PPI-G12D, and NEA-G12D of 1–10 μM, respectively.
V51425	KRas G12R inhibitor 1		KRas G12R inhibitor 1 is a selective covalent inhibitor of KRas G12R that binds irreversibly in the Switch II region of K-Ras and takes advantage of the strong nucleophilicity of mutant cysteines.
V51420	KRAS inhibitor-22	2042365-57-9	KRAS inhibitor-22 is a novel K-Ras inhibitor.
V51419	KRAS inhibitor-3	900897-56-5	KRAS inhibitor-3 is a novel KRAS inhibitor.
V51431	KRAS mutant protein inhibitor 1	2642305-16-4	KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor for potential cancer research.
V80516	KRASG12C IN-1		KRASG12C IN-1 is a potent covalent inhibitor of KRASG12C that traps KRASG12C in the GDP-bound state.
V51443	KRASG12C IN-2	2706637-12-7	KRASG12C IN-2 (compound 17) is an orally bioavailable inhibitor of KRASG12C.
V76849	KRASG12D-IN-1		KRASG12D-IN-1 (compound 22) is a KRASG12D inhibitor.
V76848	KRASG12D-IN-2		KRASG12D-IN-2 (compound 28) is a KRASG12D inhibitor.
V4791	MRTX-1257	2206736-04-9	MRTX-1257 is a novel, potent, selective, orally bioavailable and covalent / irreversible inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.
V51209	MRTX-849 acid	2561529-96-0	MRTX849 acid, a MRTX849 derivative, can be utilized to create PROTAC LC-2.
V51208	MRTX-849 ethoxypropanoic acid	2561529-98-2	MRTX849 ethoxypropanoic acid includes a PROTAC linker and a KRAS G12C ligand.
V60080	MRTX0902	2654743-22-1	MRTX0902 is an orally bioavailable inhibitor of SOS1 with IC50 of 46 nM.
V26253	NAV-2729	419547-11-8	Grassofermata (NAV-2729) is a selective ARF6 inhibitor (IC50 = 1.0 μM), or adual inhibitor of Arf1/Arf6 activation, with anticancer effects.
V51414	Opnurasib (JDQ-443; NVP-JDQ-443)	2653994-08-0	Opnurasib (JDQ-443) (NVP-JDQ443) is an orally potent and specific covalent KRAS G12C inhibitor.
V79336	PPI-GIT1/β-Pix interaction-IN-1		PPI-GIT1/β-Pix interaction-IN-1 is an orally bioavailable GIT1/β-Pix protein-protein interaction (PPI) inhibitor (antagonist) with a KD of 7.7 µM.