Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78534 | Tubulin/HDAC-IN-3 | Tubulin/HDAC-IN-3 (compound 12a) is a potent dual tubulin/HDAC inhibitor. | |
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V81650 | Tubulin/PARP-IN-1 | Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor (antagonist) with activity against endometrial cancer. | |
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V78127 | Tubulysin IM-1 | Tubulysin IM-1 is a microtubule/tubulin inhibitor and can be used as ADC Cytotoxin and anti-microtubule toxins for ADC synthesis. | |
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V32982 | Vc-MMAD | 1401963-17-4 | Vc-MMAD is composed of the ADC linker (Val-Cit) and MMAD which is a potent tubulin inhibitor. |
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V28779 | Verubulin hydrochloride (MPC-6827 hydrochloride) | 917369-31-4 | Verubulin hydrochloride (MPC-6827 hydrochloride), the hydrochloride salt of verubulin, is a quinazoline-based and BBB (blood brain barrier) permeable microtubule-disrupting agent with potential antitumor activity. |
|
V20351 | Vinblastine sulfate (NSC49842) | 143-67-9 | Vinblastine sulfate (also known as NSC49842; Vincaleukoblastine), a natural alkaloid extracted from the plant Vinca rosea Linn, is an approved anticancer drug and a potent mitotic inhibitor that inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, it is used to treat certain kinds of cancer. |
|
V81734 | Vincristine-d6 sulfate (Leurocristine-d6 (sulfate); NSC-67574-d6 (sulfate); 22-Oxovincaleukoblastine-d6 (sulfate)) | Vincristine-d6 (sulfate) is the deuterated form of Vincristine sulfate. | |
|
V3769 | Vinflunine ditartrate (BMS 710485) | 194468-36-5 | Vinflunine ditartrate (F 12158, BMS 710485)is a new analog of the vinca alkaloid vinorelbine that is bi-fluorinated strucuturally. |
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V35137 | Violanone | 52250-38-1 | Violanone is an isoflavanone compound that can inhibit tubulin polymerization. |
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V53954 | Wikstrol A | 159736-35-3 | Wikstrol A is a potent antifungal, antimitotic, and anti-HIV-1 agent. |
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