FLT3 (Fms-like tyrosine kinase 3, CD135) is a protein that in humans is encoded by the FLT3 gene.The class III receptor tyrosine kinase family includes FLT3, a cytokine receptor. FLT3 is the cytokine Flt3 ligand (FLT3L)'sreceptor. On the surface of many hematopoietic progenitor cells, FLT-3 is expressed. The normal development of hemopoietic stem cells and progenitor cells depends on FLT3 signaling. One of the genes with the highest frequency of mutations in acute myeloid leukemia (AML) is FLT3.Furthermore, high FLT3 levels in blast cells from some AML patients without FLT3 mutations have been observed. The prognosis may be worse when these levels are high. Cell proliferation, differentiation, and survival are influenced by FLT3 signaling. FLT3 is crucial for the growth of lymphocytes (B and T cells), but not for the growth of other blood cells. The cytokines TNF-Alpha and TGF-Beta both inhibit FLT3 activity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V128319 | Adezkibart | 2921564-55-6 | Adezkibart is a human monoclonal antibody immunosuppressant that targets human FMS-like tyrosine kinase 3 ligand (FLT3LG). |
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V77277 | AKN-028 acetate | AKN-028 acetate, a novel tyrosine kinase inhibitor (TKI), is a potent orally bioactive FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor (antagonist) with IC50 of 6 nM. | |
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V0587 | AMG 925 (FLX925; AMG925) | 1401033-86-0 | AMG 925 (also called FLX-925; AMG-925) is a novel, potent, selective and orally bioavailable FLT3/CDK4 dual inhibitor with potential antitumor activity. |
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V11821 | ATH686 | 853299-52-2 | ATH686 is a novel and selective FLT3 Inhibitor. |
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V129966 | BDT001 | 823837-22-5 | BDT001 is a selective FLT3 receptor antagonist that can be used in research on pain disorders, cancer, and autoimmune diseases. |
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V33217 | BPR1J-097 | 1327167-19-0 | BPR1J-097 is a novel and potent FLT3 inhibitor (antagonist) with IC50 of 11 nM. |
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V77188 | BPR1J-097 Hydrochloride | BPR1J-097 HCl is a new and potent FLT3 inhibitor (antagonist) with IC50 of 11 nM. | |
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V69488 | BPR1K871 (DBPR114) | 2443767-35-7 | BPR1K871 (DBPR114) is a potent and specific FLT3/AURKA dual (bifunctional) inhibitor (antagonist) with IC50s of 19 nM and 22 nM for FLT3 and AURKA respectively. |
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V131474 | CHEMBL4444839 | 2316841-82-2 | CHEMBL4444839 is an FLT3 inhibitor that can be used in research on acute myeloid leukemia (AML). |
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V88051 | D-65476 | 249762-74-1 | D-65476 is a type III receptor tyrosine kinase (Flt3) inhibitor. |
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V0588 | Denfivontinib (G-749) | 1457983-28-6 | G-749 (G749) is a novel and potent FLT3 inhibitor with potential antineoplastic activity. |
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V69292 | Dovitinib lactate (CHIR-258 lactate; TKI-258 lactate) | 692737-80-7 | Dovitinib lactate (TKI258 lactate) is a multi-target tyrosine kinase inhibitor, inhibiting FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β with IC50s of 1, 2, 8/9 respectively. |
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V69283 | Dovitinib-d8 (Dovitinib d8) | 1246819-84-0 | Dovitinib-d8 is the deuterated form of Dovitinib. |
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V69486 | Emavusertib hydrochloride (CA-4948 hydrochloride) | 2376399-42-5 | Emavusertib (CA-4948) HCl is a selective and orally bioactive IRAK4/FLT3 inhibitor. |
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V136094 | Flonoltinib monomaleate | Flonoltinib monomaleate is a potent and orally effective dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM, and 39 nM for JAK2, FLT3, JAK1, and JAK3, respectively. | |
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V102949 | Flonoltinib sulfate | 2568842-57-7 | Flunotinib maleate is an oral dual JAK2/FLT3 inhibitor with IC50 of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. |
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V117072 | Flt-3-IN-1 | Flt-3-IN-1 is a potent FLT-3 inhibitor with an IC50 value of 0.91 μM. | |
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V118845 | FLT3 D835Y Recombinant Human Active Protein Kinase | FLT3 (FMS-like tyrosine kinase 3, CD135) is a type 3 receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation during normal hematopoiesis. | |
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V118866 | FLT3 ITD Recombinant Human Active Protein Kinase | FLT3 (FMS-like tyrosine kinase 3, CD135) is a type 3 receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation during normal hematopoiesis. | |
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V105277 | FLT3 Ligand-Linker Conjugate 1 | 2769753-49-1 | FLT3 ligand-adapter conjugate 1 contains the FLT3 ligand and a PROTAC adaptor that recruits the E3 ligase VHL. |
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