Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.The receptor separates from supporting proteins after binding the hormone ligand, moves into the nucleus, dimerizes, and then activates transcription of androgen-responsive genes. The progesterone receptor is most similar to the androgen receptor, and progestins can block the androgen receptor when used in larger doses. The androgen receptor's primary role is that of a DNA-binding transcription factor that controls gene expression. The formation and maintenance of the male sexual phenotype depend heavily on genes that are influenced by androgen. Complete androgen insensitivity (CAIS) is a condition that is also correlated with mutations in this gene.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V67628 | LH-RH II (chicken) | 91097-16-4 | LH-RH II (chicken) is one of the two forms of luteinizing hormone-releasing hormone (LHRH) in the chicken hypothalamus and is a structural variant of mammalian LHRH. |
|
V4852 | LY-2452473 | 1029692-15-6 | LY2452473 is a novel, potent, selective and orally bioavailable androgen receptor modulator (SARM) with potential tissue-selective androgenic/anti-androgenic activity. |
|
V67596 | Masofaniten (Androgen receptor-IN-2) | 2416716-62-4 | Masofaniten (Androgen receptor-IN-2) is a potent, orally bioactive androgen receptor blocker/inhibitor. |
|
V4324 | MK-0773 | 606101-58-0 | MK-0773 (PF-05314882) is a novel and potent SARM (selective androgen receptor modulator) that binds to AR with an IC50 of 6.6 nM and with the potential for the prevention and treatment of muscle wasting associated with cancer. |
|
V40329 | N-Desmethyl Apalutamide | 1332391-11-3 | N-Desmethyl Apalutamide is the CYP2C8 and CYP3A4-mediated, N-demethylated and active metabolite of Apalutamide, but the potency is less than the parent drug. |
|
V67640 | N-Nitrosodicyclohexylamine (NDCHA) | 947-92-2 | N-Nitrosodicyclohexylamine (NDCHA) is an N-nitroso compound with anti-androgenic activity. |
|
V3988 | ORM-15341 | 1297537-33-7 | ORM-15341 is a novel, potent and full antagonist of human androgen receptor (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct. |
|
V76604 | PROTAC AR Degrader-4 TFA | PROTAC AR Degrader-4 contains IAP ligand binding group, linker and androgen receptor (AR) ligand binding group. | |
|
V81220 | PROTAC AR-NTD degrader 1 | PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule protein-targeting chimera (PROTACs) targeting the Androgen Receptor AR-V7. | |
|
V67599 | Ralaniten triacetate (EPI-506) | 1637573-04-6 | Ralaniten triacetate (EPI-506), the precursor of Ralaniten, is a first-in-class, orally bioactive androgen receptor (AR) N-terminal domain (NTD) inhibitor. |
|
V67616 | RD162 | 915087-27-3 | RD162 is a diarylthiohydantoin, an orally bioavailable nonsteroidal antiandrogen (NSAA). |
|
V67598 | Rezvilutamide (SHR3680) | 1572045-62-5 | Rezvilutamide (SHR3680) An androgen receptor blocker (antagonist). |
|
V81305 | RLA-4842 | RLA-4842 is an iron activator containing an antiandrogen. | |
|
V81306 | RLA-5331 | RLA-5331 is an antiandrogen-containing iron activator. | |
|
V14195 | S-23 | 1010396-29-8 | S-23 is an oral selective androgen receptor modulator (SARM) with Ki of 1.7 nM. |
|
V67641 | Silandrone (Testosterone trimethylsilyl ether) | 5055-42-5 | Silandrone is a synthetic, orally bioactive androgenic steroid (AAS). |
|
V4069 | Testolone (RAD140) | 1182367-47-0 | Testolone (formerly known as RAD140) is a novel, potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM) that is being investigated for the treatment of conditions such as muscle wasting and breast cancer. |
|
V67619 | TFM-4AS-1 | 188589-61-9 | TFM-4AS-1 is a selective androgen receptor modulator (SARM). |
|
V67642 | Trestolone (7α-Methylnandrolone) | 3764-87-2 | Trestolone is a synthetic androgenic steroid (AAS). |
|
V3752 | UT-155 | 2031161-35-8 | UT-155 is a potent and selective androgen receptor (AR) degrader (SARD) that markedly reduces the activity of wild-type and splice variant isoforms of AR at submicromolar doses. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
