Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.The receptor separates from supporting proteins after binding the hormone ligand, moves into the nucleus, dimerizes, and then activates transcription of androgen-responsive genes. The progesterone receptor is most similar to the androgen receptor, and progestins can block the androgen receptor when used in larger doses. The androgen receptor's primary role is that of a DNA-binding transcription factor that controls gene expression. The formation and maintenance of the male sexual phenotype depend heavily on genes that are influenced by androgen. Complete androgen insensitivity (CAIS) is a condition that is also correlated with mutations in this gene.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V80274 | Androgen receptor-IN-6 | Androgen receptor-IN-6 (compound 16) is an orally bioavailable androgen receptor (Androgen Receptor) potent inhibitor (IC50=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD). | |
|
V79263 | Anticancer agent 135 | Anticancer agent 135 (compound 26h) is a potent androgen receptor (AR) antagonist. | |
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V67613 | Apalutamide-d3 (ARN-509-d3) | 1638885-61-6 | Apalutamide-d3 is the deuterated form of Apalutamide. |
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V67605 | Apalutamide-d4 (ARN-509-d4) | 1638885-65-0 | Apalutamide-d4 is a deuterated form of Apalutamide. |
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V67607 | AR antagonist 1 hydrochloride | 1818885-55-0 | AR antagonist 1 (compound 29) HCl is a potent AR antagonist that binds to E3 ligase ligand and has weak binding affinity to VHL protein. |
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V67636 | AR antagonist 4 | 2883447-45-6 | AR antagonist 4 (Compound 67-b) is an orally bioactive androgen receptor (AR) antagonist (inhibitor) with IC50 of 246.6 nM for wild-type AR. |
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V67610 | ARD-1676 | 2632305-36-1 | ARD-1676 is an orally bioavailable androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. |
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V3472 | BMS-564929 | 627530-84-1 | BMS-564929 is anovel, highly potent, orally bioactive, nonsteroidal tissue selective androgen receptor (AR) modulator that binds to androgen receptor (AR) with aKiof 2.11±0.16 nM. |
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V78582 | BWA-522 | BWA-522 is an orally bioavailable small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7. | |
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V67606 | CLP-3094 | 312749-73-8 | CLP-3094 is a potent androgen receptor (AR) BF3 (binding function 3) inhibitor. |
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V53088 | Cyprodinil | 121552-61-2 | Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that can inhibit methionine biosynthesis by phytopathogenic fungi. |
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V32637 | D4-abiraterone | 154229-21-7 | D4-abiraterone is an active metabolite of abirateroneΔ4-Abiraterone (D4A) which is a CYP17A1 inhibitor and an androgen receptor antagonist (IC50 of 5.3 nM). |
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V11512 | Danazol | 17230-88-5 | Danazol is a novel and potent analogue of the synthetic steroid ethisteroneacting as a testosterone gonadotropin inhibitor with weak androgenic effects. |
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V34698 | Dimethomorph (Dimethomorph) | 110488-70-5 | Dimethomorph is a fungicide that belongs to the sterol biosynthesis inhibitor class of fungicides. |
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V56372 | Dimethomorph-d8 (Dimethomorph-d8) | 1346606-71-0 | Dimethomorph-d8 is the deuterium labelled form of Dimethomorph. |
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V67612 | Enzalutamide-d6 (MDV3100-d6) | 1443331-94-9 | Enzalutamide-d6 is a deuterium-labeled enzalutamide (MDV3100). |
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V67627 | Faznolutamide | 1272719-08-0 | Faznolutamide is an antiandrogenic active molecule. |
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V67611 | Gumelutamide | 1831085-48-3 | Gumelutamide is a tetrahydropyridopyrimidine compound that works as an antiandrogenic, anticancer agent. |
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V67633 | HG122 | 1854976-77-4 | HG122 promotes the degradation of androgen receptor AR by inhibiting the proteasome pathway in castration-resistant prostate cancer. |
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V3518 | KX-826 | 1272719-00-2 | This product is discontinued due to commercial reason. KX826( also known as Pyrilutamide ) is an androgen receptor (AR) antagonist and a potential first-in-class topical drug for the treatment of androgenetic alopecia (AGA) and acne vulgaris. |
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