Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.The receptor separates from supporting proteins after binding the hormone ligand, moves into the nucleus, dimerizes, and then activates transcription of androgen-responsive genes. The progesterone receptor is most similar to the androgen receptor, and progestins can block the androgen receptor when used in larger doses. The androgen receptor's primary role is that of a DNA-binding transcription factor that controls gene expression. The formation and maintenance of the male sexual phenotype depend heavily on genes that are influenced by androgen. Complete androgen insensitivity (CAIS) is a condition that is also correlated with mutations in this gene.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V81753 | WCA-814 | WCA-814 is an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate. | |
|
V4072 | YK11 | 1370003-76-1 | YK-11 is a novel, potent, synthetic, steroidal selective androgen receptor modulator (SARM) that acts as a partial agonist of androgen receptor with osteogenic activity. |
|
V67631 | YXG-158 | 2952994-34-0 | YXG-158 (Compound 23-h) is an AR degrader and CYP17A1 inhibitor (antagonist) with oral activity. |
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