White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74992 | Urabrelimab (SRF-231; SRF231) | 2249722-58-3 | Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody (mAb) that blocks the CD47-SIRP interaction. |
|
V75045 | Vamikibart | 2744320-12-3 | Vamikibart is a chimeric humanized IgG2κ antibody targeting IL-6. |
|
V75049 | Varokibart | 2643349-04-4 | Varokibart (TEV-53275) is a human IgG4λ antibody targeting IL-5. |
|
V74973 | Vixarelimab (KPL-716) | 2243320-83-2 | Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody (mAb) that binds to the β-chain of the OSM receptor and inhibits IL-31 and OSM signaling. |
|
V74968 | Vobarilizumab (ALX-0061) | 1628814-88-9 | Vobarilizumab (ALX-0061) is an anti-IL-6R monoclonal antibody (mAb) (Kd: 0.19 pM). |
|
V75048 | Temtokibart | 2733581-99-0 | Vopikitug is an IgG1-kappa, human monoclonal antibody (mAb) against IL-2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25). |
|
V74976 | Vunakizumab (Anti-Human IL17A Recombinant Antibody) | 1792181-33-9 | Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant humanized IgGκ monoclonal antibody (mAb) that targets IL-17A and inhibits its interaction with the IL-17 receptor. |
|
V75002 | Xeligekimab (GR 1501) | 2382921-73-3 | Xeligekimab (GR 1501) is a humanized monoclonal antibody (mAb) against human interleukin 17A (IL-17A). |
|
V71703 | Y13g | 2766380-73-6 | Y13g is a potent inhibitor of AChE and IL-6. |
|
V74986 | Ziltivekimab (COR-001) | 2226654-05-1 | Ziltivekimab (COR-001), a humanized anti-IL-6 monoclonal antibody (mAb), can effectively reduce serum CRP. |
|
V75007 | β-Interleukin II (44-56) | 309247-07-2 | β-Interleukin II (44-56) is the 44-56 fragment of the β-Interleukin II polypeptide. |
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