White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75014 | IL-17 modulator 9 | 1449211-26-0 | IL-17 modulator 9 (compound 453) is an orally bioactive modulator of IL-17. |
|
V74931 | IL-17A antagonist 1 | 2205034-18-8 | IL-17A antagonist 1 (compound 1) is an IL-17A antagonist (inhibitor) with a Kd of 0.66 μM and IC50 of 1.14 μM. |
|
V74981 | IL-17A antagonist 3 | 2230780-65-9 | IL-17A antagonist 3 is an IL-17A antagonist, compound 3. |
|
V74929 | IL-17A inhibitor 1 | 2452464-73-0 | IL-17A inhibitor 1 (example 24) is an inhibitor (blocker/antagonist) of IL-17A, with IC50s of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells, respectively. |
|
V75012 | IL-17A inhibitor 2 | 2452464-77-4 | IL-17A inhibitor 2 is an IL-17A inhibitor studied in psoriasis, rheumatoid arthritis, and multiple sclerosis. |
|
V74944 | IL-17A modulator-1 | 2748749-29-1 | IL-17A modulator-1 is an IL-17A modulator from patent WO2021239743+A1, example 9. |
|
V74964 | IL-17A modulator-2 | 2748749-47-3 | IL-17A modulator-2 is an IL-17A modulator from patent WO2021239743+A1, example 27. |
|
V75044 | IL-17A modulator-3 | 2467732-95-0 | IL-17A modulator-3 (compound 253) is a modulator of IL-17A. |
|
V75026 | IL-1β-IN-1 | 2780364-50-1 | IL-1β-IN-1 is a cannabidiol analogue and a potent inhibitor of IL-1β. |
|
V75035 | IL-1β-IN-2 | 2242896-76-8 | IL-1β-IN-2 is a cannabidiol analogue and a potent inhibitor of IL-1β. |
|
V74938 | IL-4-inhibitor-1 | 1332184-63-0 | IL-4-inhibitor-1 (compound 52) is an inhibitor (blocker/antagonist) of IL-4 with EC50 of 1.81 µM. |
|
V80356 | IL-6 aptamer sodium | IL-6 aptamer sodium is a nucleic acid aptamer that specifically targets IL-6 and can be used for the specific detection of IL-6. | |
|
V75019 | Imsidolimab (ANB 019) | 2102543-86-0 | Imsidolimab (ANB 019) is a high-affinity, humanized anti-IL-36R monoclonal antibody (mAb). |
|
V74960 | Inbakicept | 2135939-52-3 | Inbakicept, also known as N-803 (Nogapendekin alfa inbakicept), contains the IL-15 cytokine antibody Nogapendekin alfa. |
|
V74978 | Inolimoab | 152981-31-2 | Inolimomab is a monoclonal antibody (mAb) directed against the alpha chain of the interleukin-2 receptor (IL-2R). |
|
V76890 | Interleukin (IL)-6 Receptor | Interleukin (IL)-6 Receptor is a polypeptide extracted from the interleukin 6 receptor. | |
|
V75037 | Interleukin II (60-70) | 800379-41-3 | Interleukin II (60-70) is the 60-70 fragment of the cytokine interleukin II (Interleukin II) polypeptide. |
|
V74948 | Itepekimab (REGN-3500; SAR-440340) | 2226742-52-3 | Itepekimab (REGN-3500) is a monoclonal antibody (mAb) against IL-33. |
|
V74930 | Ixekizumab (LY2439821) | 1143503-69-8 | Ixekizumab is a humanized IgG4 monoclonal antibody (mAb) that selectively binds and neutralizes interleukin IL-17A (KD<3 pM). |
|
V74947 | Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide) | 22688-78-4 | Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide) is a conjugated metabolite of kaempferol and has anti-inflammatory effects. |
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