White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75011 | Keliximab (SB-210396; IDEC CE9.1) | 174722-30-6 | Keliximab (SB-210396) is a chimeric human/cynomolgus IgG1 anti-CD4 monoclonal antibody (mAb) with a Kd of 1.0 nM for soluble CD4. |
|
V75008 | Lck Inhibitor III | 1188890-30-3 | Lck Inhibitor III (compound 12h) is a potent Lck inhibitor (antagonist) with IC50 of 867 nM. |
|
V75001 | Levilimab (BCD-089) | 2035008-70-7 | Levilimab (BCD-089) is a fully human anti-interleukin-6 receptor (IL-6R) monoclonal antibody (mAb). |
|
V75018 | Lib2-1 | 2983116-47-6 | Lib2-1 is a macrocyclic peptide and an IL-17C/IL-17RE interaction inhibitor. |
|
V74977 | Ligufalimab (AK 117) | 2428381-55-7 | Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody (mAb). |
|
V74280 | Linderaspirone A | 1235126-46-1 | Linderaspirone A also inhibits the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), which are pro-inflammatory proteins, as well as the activation of nuclear factor kappa B (NF-κB). |
|
V74966 | Lokivetmab (Anti-Canine IL31 Recombinant Antibody) | 1533403-95-0 | Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody (mAb) for use in canine atopic dermatitis (AD) research. |
|
V74955 | Lusvertikimab (Lusvertikimab; OSE-127) | 2375835-91-7 | Lusvertikimab (OSE-127) is a humanized IL7R monoclonal antibody (mAb). |
|
V74989 | Lutikizumab (ABT-981) | 1791411-57-8 | Lutikizumab (ABT-981) is a bivariable domain immunoglobulin against IL-1α and IL-1β. |
|
V75025 | Lyn peptide inhibitor | 222018-18-0 | Lyn peptide inhibitor is a potent, cell-penetrable inhibitor that can suppress Lyn-coupled IL-5 receptor-related signaling pathways while keeping other signals intact. |
|
V80647 | Lyn peptide inhibitor TFA | Lyn peptide inhibitor TFA is a potent, cell-penetrable inhibitor that can suppress Lyn-coupled IL-5 receptor-related signaling pathways while keeping other signals intact. | |
|
V74974 | Manfidokimab (AK120) | 2428381-56-8 | Manfidokimab (AK120) is an anti-interleukin 4 receptor alpha (IL-4Rα) IgG4 monoclonal antibody (mAb). |
|
V75040 | Melredableukin alfa | 2056881-92-4 | Melredableukin alfa (RO-7049665) is a fusion protein consisting of human IgG1-κ fused to human mutant interleukin 2 (IL2 mutin) via a peptide linker. |
|
V75038 | Melrilimab (GSK 3772847; CNTO-7160) | 2222865-46-3 | Melrilimab (GSK 3772847) is an IgG2-kappa anti-IL1RL1/ST2/IL33R/DER4/FIT-1 monoclonal antibody (mAb). |
|
V74988 | Mirikizumab (LY3074828) | 1884201-71-1 | Mirikizumab (LY3074828; Omvoh) is a humanized IgG4 monoclonal antibody (mAb) targeting the p19 subunit of interleukin-23. |
|
V75021 | Myelopeptide-2 (MP-2) | 137833-31-9 | Myelopeptide-2, originally extracted from porcine bone marrow cell culture supernatants, can restore the mitogen reactivity, interleukin-2 (IL-2) synthesis levels and levels of human T lymphocytes under conditional inhibition of HL-60 leukemia cells or measles virus. |
|
V76720 | Nadunolimab | Nadunolimab is a human IgG1 monoclonal antibody (mAb) targeting IL1RAP. | |
|
V74945 | Nemolizumab (CIM331) | 1476039-58-3 | Nemolizumab (CIM331) is a humanized anti-human interleukin-31 receptor alpha monoclonal antibody (mAb) that can inhibit interleukin-31 (IL-31) binding to its receptor and subsequent signal transduction. |
|
V74994 | Nemvaleukin alfa (ALKS 4230; RDB-1450) | 2315268-27-8 | Nemvaleukin alfa (ALKS 4230) is an IL-2 fusion protein that selectively binds to the medium-affinity IL-2R. |
|
V74996 | Netakimab | 1796570-08-5 | Netakimab is an anti-IL-17 monoclonal antibody (mAb). |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
