Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
V55536 2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine 2305416-06-0 2',3',5'-Tri-O-benzoyl-5-difluoromethyluridine is a thymidine analogue.
V56012 2',3',5'-Tri-O-benzoyl-5-hydroxy methyluridine (see GL100342) 53910-92-2 2',3',5'-Tri-O-benzoyl-5-hydroxy methyluridine (see GL100342) is a thymidine analog.
V75544 2',3',5'-Tri-O-benzoyl-5-hydroxymethyl-2'-β-C-methyluridine 2305416-16-2 2',3',5'-Tri-O-benzoyl-5-hydroxymethyl-2'-β-C-methyluridine is a thymidine analogue.
V75628 2',3',5'-Tri-O-benzoyl-5-iodouridine 2880-91-3 2',3',5'-Tri-O-benzoyl-5-iodouridine is an analogue of purine nucleoside.
V55986 2',3',5'-Tri-O-benzoyl-5-methoxyuridine 37805-86-0 2',3',5'-Tri-O-benzoyl-5-methoxyuridine is an analogue of purine nucleoside.
V75681 2',3',5'-Tri-O-benzoyl-6-azauridine 1627-29-8 2',3',5'-Tri-O-benzoyl-6-azauridine is an analogue of purine nucleoside.
V55948 2',3',5'-Tri-O-benzyl-4'-thio-arabinouridine 267665-69-0 2',3',5'-Tri-O-benzyl-4'-thio-arabinouridine is an analogue of purine nucleoside.
V55790 2′,3′-Anhydroadenosine 2627-64-7 2′,3′-Anhydroadenosine is an analogue of purine nucleoside.
V55811 2',3'-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine 2305415-94-3 2',3'-Bis(O-(t-butyldimethylsilyl)-5-methoxyuridine is an analogue of purine nucleoside.
V55817 2',3'-Bis(Ot-butyldimethylsilyl)-2-thiouridine 2305415-97-6 2',3'-Bis(Ot-butyldimethylsilyl)-2-thiouridine is an analogue of purine nucleoside.
V55636 2',3'-Bis(Ot-butyldimethylsilyl)-4',5'-didehydro-5'-deoxyuridine 128070-78-0 2',3'-Bis(Ot-butyldimethylsilyl)-4',5'-didehydro-5'-deoxyuridine is a uridine nucleoside analogue.
V55526 2',3'-Bis-(Ot-butyldimethylsilyl)uridine 69504-12-7 2',3'-Bis-(Ot-butyldimethylsilyl)uridine is an analogue of purine nucleoside.
V75692 2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy guanosine 2389988-71-8 2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy guanosine is an analogue of purine nucleoside.
V55940 2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine 2389988-77-4 2',3'-Di-O-acetyl-8-benzyloxy-3'-deoxy-3'-fluoroguanosine is an analogue of purine nucleoside.
V75648 2',3'-Di-O-acetyl-D-uridine (acetic acid 4-acetoxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl- tetrahydrofuran-3-yl ester) 29108-90-5 2',3'-Di-O-acetyl-D-uridine is an analogue of purine nucleoside.
V53304 2′,3′-Di-O-acetylguanosine 42167-65-7 2′,3′-Di-O-acetylguanosine is a nucleoside analog.
V55956 2',3'-Di-O-isopropylidene-4'-alpha-C-azidouridine 690271-27-3 2',3'-Di-O-isopropylidene-4'-alpha-C-azidouridine is a uridine analog.
V55992 2′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine 15379-29-0 2′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine is an analogue of purine nucleoside.
V55500 2',3'-Didehydro-2',3'-dideoxyuridine 5974-93-6 2',3'-Didehydro-2',3'-dideoxyuridine is an analogue of purine nucleoside.
V75719 2′,3′-Dideoxy-3′-fluoro-5-methylcytidine 115249-95-1 2′,3′-Dideoxy-3′-fluoro-5-methylcytidine is an analogue of purine nucleoside.
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