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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
V75522 1-β-D-Arabinofuranosyl-5-bromo-2,4(1H,3H)-pyrimidinedione 3370-69-2 1-β-D-Arabinofuranosyl-5-bromo-2,4(1H,3H)-pyrimidinedione is an analogue of purine nucleoside.
V75912 1-β-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine 70421-30-6 1-β-D-Ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine is an analogue of purine nucleoside.
V55670 2',3',5'-Tri-O-(t-butyldimethylsilyl)-4'-C-hydroxymethyl uridine 232588-97-5 2',3',5'-Tri-O-(t-butyldimethylsilyl)-4'-C-hydroxymethyl uridine is a uridine analogue.
V55650 2',3',5'-Tri-O-acetyl adenosine (Adenosine, 2',3',5'-triacetate) 7387-57-7 2',3',5'-Tri-O-acetyl adenosine is an adenine nucleoside analogue.
V55362 2',3',5'-Tri-O-acetyl-2-thiouridine 28542-31-6 2',3',5'-Tri-O-acetyl-2-thiouridine is an analogue of purine nucleoside.
V55694 2',3',5'-Tri-O-acetyl-5,N3-dimethyluridine 201421-00-3 2',3',5'-Tri-O-acetyl-5,N3-dimethyluridine is a thymidine analogue.
V55951 2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine 84500-34-5 2',3',5'-Tri-O-acetyl-5-(trifluoromethyl)uridine is a thymidine analog.
V55813 2',3',5'-Tri-O-acetyl-5-cyanouridine 1630743-99-5 2',3',5'-Tri-O-acetyl-5-cyanouridine is a thymidine analog.
V55308 2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine 1613530-52-1 2',3',5'-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine is an analogue of purine nucleoside.
V55821 2′,3′,5′-Tri-O-acetyl-6-chloroguanosine 16321-99-6 2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is an analogue of purine nucleoside.
V55640 2',3',5'-Tri-O-acetyl-6-S-methyl-6-thio-guanosine 80681-58-9 2',3',5'-Tri-O-acetyl-6-S-methyl-6-thio-guanosine is an analogue of purine nucleoside.
V55325 2',3',5'-Tri-O-acetyl-N3-methyluridine 64623-26-3 2',3',5'-Tri-O-acetyl-N3-methyluridine is a uridine analog.
V55629 2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-6-azauridine 622379-83-3 2',3',5'-Tri-O-benzoyl-2'-beta-C-methyl-6-azauridine is an analogue of purine nucleoside.
V75764 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-3-deazauridine 2072145-54-9 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-3-deazauridine is an analogue of purine nucleoside.
V75932 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-fluorouridine 2072145-49-2 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-fluorouridine is an analogue of purine nucleoside.
V75917 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methoxy uridine 2072145-79-8 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methoxy uridine is an analogue of purine nucleoside.
V75531 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methyl uridine 957535-53-4 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methyl uridine is a thymidine analogue.
V55604 2',3',5'-Tri-O-benzoyl-2-thiouridine 21052-18-6 2',3',5'-Tri-O-benzoyl-2-thiouridine is an analogue of purine nucleoside.
V55378 2',3',5'-Tri-O-benzoyl-4-thiouridine 15049-50-0 2',3',5'-Tri-O-benzoyl-4-thiouridine is an analogue of purine nucleoside.
V55595 2',3',5'-Tri-O-benzoyl-5-azacytidine 28998-36-9 2',3',5'-Tri-O-benzoyl-5-azacytidine is a cytosine nucleoside analog.
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